Department of Pediatrics, Kansas Medical Center, Kansas City, KS, United States.
Department of Medicine and Health Sciences, "V.Tiberio" University of Molise, Campobasso, Italy.
Front Endocrinol (Lausanne). 2022 Oct 3;13:1019204. doi: 10.3389/fendo.2022.1019204. eCollection 2022.
During the last two decades, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common hepatic disease in pediatrics, mainly owing to the rising prevalence of pediatric obesity. Epidemiological studies have shown that the progressive increase in NAFLD prevalence is associated not only with obesity but also with changes in dietary habits experienced by all age groups, characterized by the increased intake of added sugars and certain fatty acids. In this review article, we focus on the effect of oxidized fatty acids deriving from linoleic acid and arachidonic acid on the pathogenesis and progression of NAFLD in youth.
在过去的二十年中，非酒精性脂肪性肝病（NAFLD）已成为儿科最常见的肝脏疾病，主要归因于儿科肥胖症的患病率不断上升。流行病学研究表明，NAFLD 患病率的逐渐增加不仅与肥胖有关，还与所有年龄段饮食习惯的变化有关，其特征是添加糖和某些脂肪酸的摄入量增加。在这篇综述文章中，我们重点关注来自亚油酸和花生四烯酸的氧化脂肪酸对青少年 NAFLD 的发病机制和进展的影响。
