Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA.
Institute for Innovation and Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31009 Pamplona, Spain.
Nutrients. 2021 May 12;13(5):1621. doi: 10.3390/nu13051621.
Non-alcoholic fatty liver disease impacts 15.2% of Hispanic adolescents and can progress to a build-up of scared tissue called liver fibrosis. If diagnosed early, liver fibrosis may be reversible, so it is necessary to understand risk factors. The aims of this study in 59 Hispanic adolescents with obesity were to: (1) identify potential biological predictors of liver fibrosis and dietary components that influence liver fibrosis, and (2) determine if the association between dietary components and liver fibrosis differs by genotype, which is highly prevalent in Hispanic adolescents and associated with elevated liver fat. We examined liver fat and fibrosis, genotyped for gene, and assessed diet via 24-h diet recalls. The prevalence of increased fibrosis was 20.9% greater in males, whereas participants with the GG genotype showed 23.7% greater prevalence. Arachidonic acid was associated with liver fibrosis after accounting for sex, genotype, and liver fat (β = 0.072, = 0.033). Intakes of several dietary types of unsaturated fat have different associations with liver fibrosis by genotype after accounting for sex, caloric intake, and liver fat. These included monounsaturated fat (β = -0.0007, β = 0.03, -value = 0.004), polyunsaturated fat (β = -0.01, β = 0.02, -value = 0.01), and omega-6 (β = -0.0102, β = 0.028, -value = 0.01). Results from this study suggest that reduction of arachidonic acid and polyunsaturated fatty acid intake might be important for the prevention of non-alcoholic fatty liver disease progression, especially among those with risk alleles.
非酒精性脂肪性肝病影响 15.2%的西班牙裔青少年，并可发展为称为肝纤维化的疤痕组织积聚。如果早期诊断，肝纤维化可能是可逆的，因此有必要了解危险因素。本研究旨在：(1)确定肥胖的 59 名西班牙裔青少年肝纤维化的潜在生物学预测因子和影响肝纤维化的饮食成分；(2)确定饮食成分与肝纤维化之间的关联是否因基因型而异，基因型在西班牙裔青少年中高度流行，并与肝脂肪升高相关。我们检查了肝脏脂肪和纤维化，对 基因进行了基因分型，并通过 24 小时饮食回忆评估了饮食。男性纤维化增加的患病率高 20.9%，而 GG 基因型的参与者则高 23.7%。在考虑性别、基因型和肝脂肪的情况下，花生四烯酸与肝纤维化相关（β=0.072， =0.033）。考虑到性别、热量摄入和肝脂肪，几种不饱和脂肪的饮食类型与基因型后与肝纤维化的关联不同。其中包括单不饱和脂肪（β=-0.0007，β=0.03，-值=0.004）、多不饱和脂肪（β=-0.01，β=0.02，-值=0.01）和 ω-6（β=-0.0102，β=0.028，-值=0.01）。本研究结果表明，减少花生四烯酸和多不饱和脂肪酸的摄入可能对预防非酒精性脂肪性肝病的进展很重要，尤其是对那些具有 风险等位基因的人。
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