Kose M, Senkal N, Tukek T, Cebeci T, Atalar S C, Altinkaynak M, Arici H, Genc S, Catma Y, Kocaaga M, Medetalibeyoglu A, Emet S
Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):7046-7052. doi: 10.26355/eurrev_202210_29888.
Vitamin D has beneficial effects, some of which involve the cardiovascular system. No study to date has investigated the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in the absence of subclinical atherosclerosis detected by carotid intima-media thickness (CIMT) in healthy individuals.
Subjects were categorized into three groups based on vitamin D levels according to Endocrine Society guidelines. Mean CIMT was calculated from six measurements on two scans. Statistical significance was set at p < 0.05, and all testing was two-sided.
The concentration of serum endocan was 802.8 ± 411.4 ng/L in the group with the lowest serum vitamin D level, 454.8 ± 334.3 ng/L in the mild/moderately low serum vitamin D level group, and 269.4 ± 180.2 ng/L in the group with normal serum vitamin D levels (p < 0.01). Receiver operating characteristics curve analysis revealed that a serum vitamin D concentration of 7.5 ng/mL had a 97% sensitivity and 81% specificity for the prediction of serum endocan level greater than 270 ng/L, which could be an indicator for endothelial inflammation.
Demonstrating that vitamin D deficiency can cause endothelial damage in the early period of atherosclerosis without the development of clinical cardiovascular disease will have a pivotal role in the prevention of cardiovascular mortality and morbidity.
维生素D具有有益作用，其中一些作用涉及心血管系统。迄今为止，尚无研究在未通过颈动脉内膜中层厚度（CIMT）检测到亚临床动脉粥样硬化的健康个体中，调查作为内皮炎症生物标志物的血清内脂素水平与维生素D水平之间的关联。
根据内分泌学会指南，根据维生素D水平将受试者分为三组。平均CIMT由两次扫描的六次测量值计算得出。统计学显著性设定为p < 0.05，所有检验均为双侧检验。
血清维生素D水平最低组的血清内脂素浓度为802.8±411.4 ng/L，血清维生素D水平轻度/中度降低组为454.8±334.3 ng/L，血清维生素D水平正常组为269.4±180.2 ng/L（p < 0.01）。受试者工作特征曲线分析显示，血清维生素D浓度为7.5 ng/mL时，预测血清内脂素水平高于270 ng/L的敏感性为97%，特异性为81%，而血清内脂素水平高于270 ng/L可能是内皮炎症指标。
证明维生素D缺乏在动脉粥样硬化早期可导致内皮损伤而无临床心血管疾病发生，将在预防心血管疾病死亡率和发病率方面发挥关键作用。
