Department of Oncologic and Gastro-Intestinal Surgery, Academic Breast Cancer Center, Erasmus University Medical Center Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Qual Life Res. 2023 Feb;32(2):373-381. doi: 10.1007/s11136-022-03271-3. Epub 2022 Oct 20.
Normative utility scores represent the health related quality of life of the general population, are of utmost importance in cost-effectiveness studies and should reflect relevant sexes and age groups. The aim of this study was to estimate EQ-5D-5L normative utility scores in a population of Dutch females, stratified by age, and to compare these scores to those of female populations of three other countries.
Dutch women completed the EQ-5D-5L online between January and July 2020. Mean normative utilities were computed using the Dutch EQ-5D-5L value set, stratified by age, tested for differences using the Kruskall-Wallis test, and compared to normative utility scores of female populations elsewhere. Additionally, to support the use of the Dutch EQ-5D-5L data in other settings, normative utility scores were also calculated by applying the value sets of Germany, United Kingdom and USA.
Data of 9037 women were analyzed and the weighted mean utility score was 0.911 (SD 0.155, 95% CI 0.908-0.914). The mean normative utility scores differed between age groups, showing lower scores in older females. Compared to other normative utility scores of female populations, Dutch mean utilities were consistently higher except for age groups 18-24 and 25-34. With the three country-specific value sets, new age-specific mean normative utility scores were provided.
This study provides mean normative utility scores of a large cohort of Dutch females per age group, which were found to be lower in older age groups. Utility scores calculated with three other value sets were made available.
规范效用评分代表一般人群的健康相关生活质量，在成本效益研究中至关重要，并且应该反映相关的性别和年龄组。本研究的目的是估计荷兰女性人群的 EQ-5D-5L 规范效用评分，按年龄分层，并将这些评分与其他三个国家的女性人群进行比较。
荷兰女性于 2020 年 1 月至 7 月期间在线填写 EQ-5D-5L。使用荷兰 EQ-5D-5L 值集计算平均规范效用，按年龄分层，使用 Kruskal-Wallis 检验检验差异，并与其他地方的女性人群的规范效用评分进行比较。此外，为了支持在其他环境中使用荷兰 EQ-5D-5L 数据，还通过应用德国、英国和美国的价值集计算了规范效用评分。
分析了 9037 名女性的数据，加权平均效用评分为 0.911（SD 0.155，95%CI 0.908-0.914）。平均规范效用评分在不同年龄组之间存在差异，老年女性的评分较低。与其他女性人群的规范效用评分相比，荷兰的平均效用评分普遍较高，但 18-24 岁和 25-34 岁年龄组除外。使用三个国家特定的价值集，提供了新的年龄特异性平均规范效用评分。
本研究提供了每个年龄组的荷兰女性大量队列的平均规范效用评分，发现年龄较大的女性评分较低。还提供了使用其他三个价值集计算的效用评分。
