Lowrie Nele, Le Bas Genevieve, Youssef George, Macdonald Jacqui A, Teague Samantha, Rogers Alana, Sunderland Matthew, Mattick Richard, Elliott Elizabeth J, Allsop Steve, Burns Lucinda, Najman Jake, Jacobs Sue, Olsson Craig A, Hutchinson Delyse
Deakin University, Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Geelong, Australia.
Deakin University, Centre for Social and Early Emotional Development, School of Psychology, Faculty of Health, Geelong, Australia; Murdoch Children's Research Institute, Centre for Adolescent Health, Royal Children's, Hospital, Melbourne, Australia; University of Melbourne, Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia.
J Psychiatr Res. 2022 Dec;156:206-213. doi: 10.1016/j.jpsychires.2022.10.017. Epub 2022 Oct 7.
The current study examined associations between preconception diagnoses of major depressive disorder (MDD) and anxiety disorders in adolescence and young adulthood and perinatal depression and anxiety symptoms in early fatherhood. In an Australian community cohort study of health and development, earlier history of MDD and anxiety disorders (extending back to adolescence) were assessed retrospectively in the third trimester of pregnancy via the Composite International Diagnostic Interview. Paternal perinatal depression and anxiety were then assessed prospectively over three timepoints (third trimester of pregnancy, 8 weeks and 12 months postpartum), using established cut-points on the Edinburgh Postnatal Depression Scale and the Depression Anxiety Stress Scales (anxiety subscale). Mixed-effects regression models examined risk associations between preconception diagnoses of MDD and anxiety disorders, and perinatal depression and anxiety symptoms at each timepoint, adjusting for socio-demographic factors and concurrent maternal mental health difficulties. The odds of clinically concerning levels of paternal perinatal depression and anxiety were 6-fold and 4-fold higher, respectively, in men with a preconception history of MDD. The odds of perinatal depression were 3-fold higher in men with a preconception history of an anxiety disorder. Less evidence was found for an association between preconception diagnoses of an anxiety disorder and perinatal anxiety in fathers. Interventions aimed at improving mental health in men during adolescence and young adulthood may promote continued psychological health in men during early fatherhood.
本研究调查了青少年和青年期重度抑郁症（MDD）及焦虑症的孕前诊断与初为人父早期的围产期抑郁和焦虑症状之间的关联。在一项澳大利亚关于健康与发育的社区队列研究中，通过综合国际诊断访谈，在妊娠晚期对MDD和焦虑症的早期病史（追溯至青少年期）进行回顾性评估。然后，使用爱丁堡产后抑郁量表和抑郁焦虑压力量表（焦虑分量表）的既定切点，在三个时间点（妊娠晚期、产后8周和12个月）对父亲的围产期抑郁和焦虑进行前瞻性评估。混合效应回归模型检验了MDD和焦虑症的孕前诊断与各时间点围产期抑郁和焦虑症状之间的风险关联，并对社会人口学因素和母亲同时存在的心理健康问题进行了调整。有MDD孕前病史的男性，其围产期抑郁和焦虑达到临床关注水平的几率分别高出6倍和4倍。有焦虑症孕前病史的男性，其围产期抑郁的几率高出3倍。在父亲中，孕前焦虑症诊断与围产期焦虑之间的关联证据较少。旨在改善男性在青少年和青年期心理健康的干预措施，可能会促进男性在初为人父早期持续保持心理健康。
