一种用于评估变力性反应的简单实验指标。

A simple experimental index for the evaluation of inotropic responses.

作者信息

Chan S H, Ong B T

出版信息

J Pharmacol Methods. 1987 Aug;18(1):23-9. doi: 10.1016/0160-5402(87)90014-3.

Abstract

The validity of the first derivative of systemic arterial pressure (SAdP/dt) as an indirect experimental index for the evaluation of inotropic responses was ascertained in rats anesthetized with pentobarbital sodium (40 mg/kg, i.p.), using the first derivative of left ventricular pressure (LVdP/dt) as the reference. We observed highly significant qualitative and quantitative (p less than 0.001) correlations between these two parameters, under five well-established experimental cardiovascular perturbations that are known to promote inotropic actions, viz, vagosympathetic trunk stimulation; intravenous administration of pentobarbital, epinephrine, or phenylephrine; and temporary common carotid artery occlusion. Preliminary experiments using isometric ventricular contraction as the reference also confirmed these observations. It is suggested that the SAdP/dt may qualify, at the systemic level, as an easily accessible experimental index for ventricular contractility.

摘要

以左心室压力一阶导数（LVdP/dt）作为参考，在戊巴比妥钠（40mg/kg，腹腔注射）麻醉的大鼠中，确定了体动脉压一阶导数（SAdP/dt）作为评价变力反应间接实验指标的有效性。在已知可促进变力作用的五种成熟的实验性心血管扰动下，即迷走交感干刺激；静脉注射戊巴比妥、肾上腺素或去氧肾上腺素；以及临时阻断颈总动脉，我们观察到这两个参数之间存在高度显著的定性和定量相关性（p<0.001）。使用等长心室收缩作为参考的初步实验也证实了这些观察结果。提示SAdP/dt在系统水平上可能符合作为一种易于获取的心室收缩性实验指标的条件。