Zhao Xingyun, Wang Shifen, Wang Shengjun, Xie Jue, Cui Dawei
Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, China; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
Clin Immunol. 2022 Dec;245:109153. doi: 10.1016/j.clim.2022.109153. Epub 2022 Oct 17.
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiorgan involvement and marked variability in clinical presentation. SLE pathogenesis includes regulatory T cell dysfunction and antinuclear antibody production. Mammalian target of rapamycin (mTOR), a serine/threonine kinase in the phosphoinositide 3-kinase (PI3K)-related kinase family, is a therapeutic target for autoimmune diseases such as SLE. Rapamycin, an inhibitor of the mTOR signaling pathway, is a macrolide antibiotic with potent immunosuppressive, antiproliferative and antifibrotic effects. Recently, an increasing number of studies have investigated the role of mTOR in regulatory T (Treg) cells and its impact on SLE pathogenesis. This review aims to systematically summarize the role of the mTOR signaling pathway in SLE pathogenesis, Treg cell dysfunction and SLE treatment.
系统性红斑狼疮（SLE）是一种典型的自身免疫性疾病，其特征为多器官受累且临床表现差异显著。SLE的发病机制包括调节性T细胞功能障碍和抗核抗体产生。雷帕霉素靶蛋白（mTOR）是磷酸肌醇3激酶（PI3K）相关激酶家族中的一种丝氨酸/苏氨酸激酶，是SLE等自身免疫性疾病的治疗靶点。雷帕霉素是mTOR信号通路的抑制剂，是一种具有强大免疫抑制、抗增殖和抗纤维化作用的大环内酯类抗生素。最近，越来越多的研究探讨了mTOR在调节性T（Treg）细胞中的作用及其对SLE发病机制的影响。本综述旨在系统总结mTOR信号通路在SLE发病机制、Treg细胞功能障碍及SLE治疗中的作用。
