在培养皿中模拟 PTSD 神经元应激反应。
Modeling PTSD neuronal stress responses in a dish.
机构信息
Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA.
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
出版信息
Nat Neurosci. 2022 Nov;25(11):1402-1404. doi: 10.1038/s41593-022-01172-9.
Abstract
How genetic and environmental risk factors interact to trigger the development of post-traumatic stress disorder (PTSD) remains largely unknown. Seah et al. model stress hypersensitivity as a potential mechanism by examining transcriptomic responses to glucocorticoids in neurons derived from individuals with PTSD.
摘要
遗传和环境风险因素如何相互作用引发创伤后应激障碍（PTSD）尚不清楚。 Seah 等人通过检查 PTSD 个体来源的神经元对糖皮质激素的转录组反应，将应激敏感性建模为一种潜在机制。
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