Department of Child and Adolescent Psychiatry, Ankara Yıldırım Beyazıt University Yenimahalle Research and Training Hospital, Ankara, Turkey.
Eur J Pediatr. 2024 Nov 25;184(1):41. doi: 10.1007/s00431-024-05889-6.
Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. The aim of this study is to assess the NSE levels in patients diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Blood samples were collected from 43 individuals with PTSD (age range 11-17), 43 individuals with MDD (age range 10-17), and 40 age- and gender-matched healthy controls. The NSE levels were analyzed, and participants completed the Post-traumatic Stress Reaction Index, the Children's Depression Inventory, and the Screen for Child Anxiety Related Disorders. Additionally, the Clinical Global Impressions Scale was filled out by the researcher. Results indicated that the NSE levels in the PTSD group were significantly higher than those in both the MDD group and the healthy control group. No significant difference in NSE levels was observed between the MDD group and the healthy control group.
The findings suggest that elevated NSE levels in PTSD may be indicative of stress-related neuronal damage, distinguishing PTSD from MDD and healthy controls. These results underline the need for further research to explore the potential of NSE as a biomarker for PTSD and its implications for diagnosis and intervention strategies.
• Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. • Elevated NSE levels have been observed in certain neuropsychiatric and neurological conditions, reflecting neuronal damage or stress.
• NSE levels in adolescents with PTSD are significantly higher than those in both MDD patients and healthy controls, suggesting a specific association with trauma-related neuronal damage. • No significant difference in NSE levels was observed between MDD patients and healthy controls, highlighting the distinct neurobiological impact of trauma compared to depressive disorders.
神经元特异性烯醇化酶（NSE）是一种神经元细胞损伤的生物标志物。本研究旨在评估诊断为创伤后应激障碍（PTSD）和重度抑郁症（MDD）的患者的 NSE 水平。采集了 43 名 PTSD 患者（年龄范围 11-17 岁）、43 名 MDD 患者（年龄范围 10-17 岁）和 40 名年龄和性别匹配的健康对照者的血样。分析了 NSE 水平，参与者完成了创伤后应激反应指数、儿童抑郁量表和儿童焦虑相关障碍筛查。此外，研究者填写了临床总体印象量表。结果表明，PTSD 组的 NSE 水平明显高于 MDD 组和健康对照组。MDD 组和健康对照组之间 NSE 水平无显著差异。
研究结果表明，PTSD 中 NSE 水平升高可能表明与应激相关的神经元损伤，将 PTSD 与 MDD 和健康对照组区分开来。这些结果强调了需要进一步研究探索 NSE 作为 PTSD 生物标志物的潜力及其对诊断和干预策略的意义。
神经元特异性烯醇化酶（NSE）是一种神经元细胞损伤的生物标志物。
在某些神经精神和神经疾病中观察到 NSE 水平升高，反映了神经元损伤或应激。
PTSD 青少年的 NSE 水平明显高于 MDD 患者和健康对照组，表明与创伤相关的神经元损伤存在特定关联。
MDD 患者和健康对照组之间 NSE 水平无显著差异，突出了创伤与抑郁障碍相比对神经生物学的影响不同。
