Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Finland.
Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Finland.
FEBS Lett. 2023 Mar;597(5):601-607. doi: 10.1002/1873-3468.14521. Epub 2022 Oct 28.
Extracellular signal-regulated kinase 7 (ERK7), also known as ERK8 and MAPK15, is an atypical member of the MAP kinase family. Compared with other MAP kinases, the biological roles of ERK7 remain poorly understood. Recent work, however, has revealed several novel functions for ERK7. These include a highly conserved essential role in ciliogenesis, the ability to control cell growth, metabolism and autophagy, as well as the maintenance of genomic integrity. ERK7 functions through phosphorylation-dependent and -independent mechanisms and it is activated by cellular stressors, including DNA-damaging agents, and nutrient deprivation. Here, we summarize recent developments in understanding ERK7 function, emphasizing its conserved roles in cellular and physiological regulation.
细胞外信号调节激酶 7（ERK7），也称为 ERK8 和 MAPK15，是 MAP 激酶家族中的一个非典型成员。与其他 MAP 激酶相比，ERK7 的生物学作用仍知之甚少。然而，最近的研究揭示了 ERK7 的几个新功能。这些功能包括在纤毛发生中具有高度保守的必需作用，能够控制细胞生长、代谢和自噬，以及维持基因组完整性。ERK7 通过依赖于磷酸化和不依赖于磷酸化的机制发挥作用，并被细胞应激物激活，包括 DNA 损伤剂和营养剥夺。在这里，我们总结了理解 ERK7 功能的最新进展，强调了其在细胞和生理调节中的保守作用。
