Wei Guangmin, Pan Yinghao, Wang Jingying, Xiong Xia, He Yuanmin, Xu Jixiang
Department of Dermatology, Medical Center Hospital of Qionglai City, Qionglai, Sichuan, People's Republic of China.
Department of Dermatology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China.
Clin Cosmet Investig Dermatol. 2022 Oct 13;15:2177-2186. doi: 10.2147/CCID.S381432. eCollection 2022.
Vitiligo is a chronic depigmenting disorder of the skin and mucosa caused by the destruction of epidermal melanocytes. Although the exact mechanism has not been elucidated, studies have shown that oxidative stress plays an important role in the pathogenesis of vitiligo. High mobility group box protein B1 (HMGB1) is a major nonhistone protein and an extracellular proinflammatory or chemotactic molecule that is actively secreted or passively released by necrotic cells. Recent data showed that HMGB1 is overexpressed in both blood and lesional specimens from vitiligo patients. Moreover, oxidative stress triggers the release of HMGB1 from keratinocytes and melanocytes, indicating that HMGB1 may participate in the pathological process of vitiligo. Overall, this review mainly focuses on the role of HMGB1 in the potential mechanisms underlying vitiligo depigmentation under oxidative stress. In this review, we hope to provide new insights into vitiligo pathogenesis and treatment strategies.
白癜风是一种由表皮黑素细胞破坏引起的皮肤和黏膜慢性色素脱失性疾病。尽管确切机制尚未阐明，但研究表明氧化应激在白癜风的发病机制中起重要作用。高迁移率族蛋白B1（HMGB1）是一种主要的非组蛋白，是一种细胞外促炎或趋化分子，由坏死细胞主动分泌或被动释放。最近的数据显示，HMGB1在白癜风患者的血液和皮损标本中均过度表达。此外，氧化应激触发角质形成细胞和黑素细胞释放HMGB1，表明HMGB1可能参与白癜风的病理过程。总体而言，本综述主要关注HMGB1在氧化应激下白癜风色素脱失潜在机制中的作用。在本综述中，我们希望为白癜风的发病机制和治疗策略提供新的见解。
