Dian Tjahyadi, Adhi Pribadi, Subhan Darojat Ar Rizqi, Aisyah Shofiatun Nisa, Tono Djuwantono
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Bandung Fertility Center, Limijati Women and Children Hospital, Bandung, Indonesia.
Ann Med Surg (Lond). 2022 Sep 16;82:104620. doi: 10.1016/j.amsu.2022.104620. eCollection 2022 Oct.
Adenomyosis (benign gynecological disease) is an endometrial stromal tissue condition that invades the myometrium of the uterus. The administration of a gonadotropin-releasing hormone (GnRH) analog before the IVF (In Vitro Fertilization) cycle significantly increases the chances of getting pregnant in adenomyosis patient with infertile condition. There is no best protocol consensus for adenomyosis for now. This study plans to compare the outcomes of long-protocol and short-protocol of IVF in adenomyosis patients who have undergone surgery and treatment with GnRH analogs.
This study is a retrospective study with a comparative method. The study was conducted at the IVF Aster Clinic and the IVF Bandung Fertility Center by reviewing retrospective data from 2015 to 2021. Patients who have been diagnosed with adenomyosis will undergo IVF procedure with a long-protocol and short-protocol pretreatment. Parameters observed were oocyte count, fertilization, and pregnancy rate.
Fifty-eight patients were included. There was a significant difference in the oocytes count and the pregnancy rate in short and long groups with p value of less than 0.05, while there was no significant difference in fertilization rate with p value of greater than 0.05.
There were differences in the oocytes count and pregnancy rates in the short and long protocol groups in adenomyosis patients. There was no difference in fertilization rate in the short and long protocol groups in adenomyosis patients.
子宫腺肌病（一种良性妇科疾病）是一种子宫内膜间质组织侵入子宫肌层的病症。在体外受精（IVF）周期前使用促性腺激素释放激素（GnRH）类似物，可显著提高患有子宫腺肌病的不孕患者的受孕几率。目前，针对子宫腺肌病尚无最佳方案共识。本研究计划比较接受过手术及GnRH类似物治疗的子宫腺肌病患者在IVF长方案和短方案中的治疗效果。
本研究为采用对比方法的回顾性研究。通过回顾2015年至2021年的回顾性数据，在IVF Aster诊所和万隆IVF生育中心开展研究。已确诊子宫腺肌病的患者将接受长方案和短方案预处理的IVF程序。观察的参数包括卵母细胞计数、受精情况和妊娠率。
纳入58例患者。短方案组和长方案组的卵母细胞计数和妊娠率存在显著差异，p值小于0.05，而受精率无显著差异，p值大于0.05。
子宫腺肌病患者中，短方案组和长方案组的卵母细胞计数和妊娠率存在差异。子宫腺肌病患者中，短方案组和长方案组的受精率无差异。
