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头皮侵袭性皮肤鳞状细胞癌:一例报告。

Invasive cutaneous squamous cell carcinoma of scalp: A case report.

作者信息

Dahal Alok, Neupane Durga, Lageju Nimesh, Jaiswal Lokesh Shekher, Chaudhary Sushant, Budhathoki Arpana Chhetri, Sah Shiva Pratik, Subedi Sushil Sharma

机构信息

Department of Surgery (Division of Neurosurgery), B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Department of Surgery, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

出版信息

Ann Med Surg (Lond). 2022 Sep 15;82:104702. doi: 10.1016/j.amsu.2022.104702. eCollection 2022 Oct.

Abstract

INTRODUCTION AND IMPORTANCE

Cutaneous Squamous cell carcinoma(cSCC) represents approximately 16% of scalp tumors. Overall, cSCC is significantly more common in the oropharyngeal mucosa than the skin. Smoking is a risk factor for mucosal lesions, risk factors for developing cutaneous SCC include age, ultraviolet light exposure, chronic scarring, history of ionizing radiation, androgenetic alopecia (in men), and immunosuppression. The rates of bone invasion in cutaneous SCC have not been well noted in the literature.

CASE REPORT

We report a case of 57-year-old man with invasive squamous cell carcinoma of scalp with extension into bone, cortex and dura mater. Gross total removal of the tumor with extension of bony defect followed by repair of dura and repair of skin defect by VY advancement flap was done under general anaesthesia. At a 3-month follow-up, his wound is well healed. No evidence of metastasis is noted.

DISCUSSION

Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, and its incidence is steadily increasing. Although the majority of cSCCs are successfully eradicated by surgical excision, advanced cSCC poses a significant risk in terms of morbidity, impact on quality of life, and risk of death.

CONCLUSIONS

Invasive cutaneous squamous cell carcinoma of scalp is a rare entity. Invasion to bone, cortex, and dura mater is furthermore rare. Therefore, proper management of advanced cSCC is of the utmost importance since local invasion, delayed diagnosis, and metastasis contribute to increased costs and morbidity. A multi-disciplinary team approach is recommended.

摘要

引言与重要性

皮肤鳞状细胞癌(cSCC)约占头皮肿瘤的16%。总体而言,cSCC在口咽黏膜比在皮肤中更为常见。吸烟是黏膜病变的危险因素,皮肤鳞状细胞癌的发病危险因素包括年龄、紫外线暴露、慢性瘢痕形成、电离辐射史、雄激素性脱发(男性)和免疫抑制。皮肤鳞状细胞癌的骨侵犯发生率在文献中尚未得到充分记载。

病例报告

我们报告一例57岁男性,患有头皮浸润性鳞状细胞癌,肿瘤侵犯至骨、皮质和硬脑膜。在全身麻醉下,对肿瘤进行了根治性切除,并扩大了骨缺损,随后修复硬脑膜,采用V-Y推进皮瓣修复皮肤缺损。在3个月的随访中,他的伤口愈合良好,未发现转移迹象。

讨论

皮肤鳞状细胞癌(cSCC)是第二常见的非黑色素瘤皮肤癌,其发病率正在稳步上升。尽管大多数cSCC通过手术切除成功根除,但晚期cSCC在发病率、对生活质量的影响和死亡风险方面构成重大风险。

结论

头皮浸润性皮肤鳞状细胞癌是一种罕见的疾病。侵犯至骨、皮质和硬脑膜的情况更为罕见。因此,晚期cSCC的妥善管理至关重要,因为局部侵犯、延迟诊断和转移会导致成本增加和发病率上升。建议采用多学科团队方法。

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