慢性血液透析患者透析后疲劳与血清S100B蛋白：一项初步研究

Post-dialysis fatigue and serum S100B protein in patients on chronic hemodialysis. A pilot study.

作者信息

Bossola Maurizio, Picca Anna, Marzetti Emanuele, Pepe Gilda, Antocicco Manuela, Di Stasio Enrico

机构信息

Servizio Emodialisi, Policlinico Universitario Fondazione A. Gemelli IRCCS, Roma, Italy.

Università Cattolica del Sacro Cuore, Roma, Italy.

出版信息

Ther Apher Dial. 2023 Jun;27(3):471-479. doi: 10.1111/1744-9987.13944. Epub 2022 Nov 1.

DOI:10.1111/1744-9987.13944

PMID:36271906

Abstract

BACKGROUND

Aim of the present study was to assess whether post-dialysis fatigue (PDF) may be related to pre- or post-dialysis levels of serum S100B protein. Hemodialysis patients (HD) who answered to be fatigued after their hemodialysis sessions when asked: "Do you feel worse after dialysis? if they answered yes" were considered to suffer from PDF. Serum Interleukins (IL-1β, IL-6, IL-10), TNF-α and S100B were assessed by ELISA kit.

RESULTS

Thirty HD patients were studied: 22 (73.4%) reported to suffer from PDF. Serum S100B post-dialysis levels (median [IQR] = 17.4 μg [7.1 to 30.9]) were significantly higher than serum S100B pre-dialysis levels (median [IQR] = 5 μg [1.4 to 22.1]; p = 0.0001). S100B post-dialysis was significantly higher than S100B pre-dialysis either in patients with PDF or without PDF.

CONCLUSIONS

Pre- and post-dialysis values of serum S100B and its delta did not differ significantly between patients with and without PDF and were not associated with the length of the TIRD in patients on chronic hemodialysis.

摘要

背景

本研究的目的是评估透析后疲劳（PDF）是否可能与透析前或透析后血清S100B蛋白水平相关。当被问及“透析后你感觉更糟吗？如果回答是”，那些回答在血液透析治疗后感到疲劳的血液透析患者（HD）被认为患有PDF。通过ELISA试剂盒评估血清白细胞介素（IL-1β、IL-6、IL-10）、TNF-α和S100B。

结果

研究了30例HD患者：22例（73.4%）报告患有PDF。透析后血清S100B水平（中位数[四分位间距]=17.4μg[7.1至30.9]）显著高于透析前血清S100B水平（中位数[四分位间距]=5μg[1.4至22.1]；p=0.0001）。无论有无PDF的患者，透析后S100B均显著高于透析前。