Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Cologne, Germany.
Int Ophthalmol. 2023 Apr;43(4):1437-1449. doi: 10.1007/s10792-022-02537-6. Epub 2022 Oct 22.
Graves ophthalmopathy (GO), which occurs in autoimmune thyroid disease, can reduce patients' quality of life due to its impact on visual function, physical appearance, and emotional health. Corticosteroids have been the first-line treatment for GO. More recently, the pathogenesis of GO has made significant progress. Various targeting biological agents and immunosuppressive agents make GO management more promising. Fully understanding GO pathogenesis and precise clinical management are beneficial for the prognosis of patients. Therefore, we conducted a comprehensive review of the medical management of GO and summarized research developments to highlight future research issues.
格雷夫斯眼病(GO)发生于自身免疫性甲状腺疾病,其对视功能、外观和情绪健康的影响可降低患者的生活质量。糖皮质激素一直是 GO 的一线治疗药物。最近,GO 的发病机制取得了重大进展。各种靶向生物制剂和免疫抑制剂使 GO 的治疗更有前景。全面了解 GO 的发病机制和精确的临床管理有利于患者的预后。因此,我们对 GO 的医学治疗进行了全面综述,并总结了研究进展,以突出未来的研究问题。