Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, 238 Baidi Road, 300192, Tianjin, China.
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, 238 Baidi Road, 300192, Tianjin, China.
Environ Pollut. 2023 Jan 1;316(Pt 2):120424. doi: 10.1016/j.envpol.2022.120424. Epub 2022 Oct 19.
The major health risks of dual exposure to two hazardous factors of plastics and radioactive contamination are obscure. In the present study, we systematically evaluated the combinational toxic effects of tetrabromobisphenol A (TBBPA), one of the most influential plastic ingredients, mainly from electronic wastes, and γ-irradiation in zebrafish for the first time. TBBPA (0.25 μg/mL for embryos and larvae, 300 μg/L for adults) contamination aggravated the radiation (6 Gy for embryos and larvae, 20 Gy for adults)-induced early dysplasia and aberrant angiogenesis of embryos, further impaired the locomotor vitality of irradiated larvae, and worsened the radioactive multiorganic histologic injury, neurobehavioural disturbances and dysgenesis of zebrafish adults as well as the inter-generational neurotoxicity in offspring. TBBPA exaggerated the radiative toxic effects not only by enhancing the inflammatory and apoptotic response but also by further unbalancing the endocrine system and disrupting the underlying gene expression profiles. In conclusion, TBBPA exacerbates radiation-induced injury in zebrafish, including embryos, larvae, adults and even the next generation. Our findings provide new insights into the toxicology of TBBPA and γ-irradiation, shedding light on the severity of cocontamination of MP components and radioactive substances and thereby inspiring novel remediation and rehabilitation strategies for radiation-injured aqueous organisms and radiotherapy patients.
双暴露于塑料和放射性污染这两种危险因子的主要健康风险尚不明确。在本研究中，我们首次系统评估了四溴双酚 A（TBBPA）与γ辐照在斑马鱼体内的联合毒性效应。TBBPA（胚胎和幼鱼为 0.25μg/mL，成鱼为 300μg/L）污染加剧了辐射（胚胎和幼鱼 6Gy，成鱼 20Gy）引起的胚胎早期发育不良和血管异常形成，进一步损害了辐照幼鱼的运动活力，并加重了放射性多器官组织损伤、斑马鱼成鱼的神经行为障碍和生殖障碍以及子代的跨代神经毒性。TBBPA 不仅通过增强炎症和凋亡反应，而且通过进一步破坏内分泌系统和扰乱潜在基因表达谱，放大了辐射的毒性效应。总之，TBBPA 加剧了辐射诱导的斑马鱼损伤，包括胚胎、幼鱼、成鱼甚至下一代。我们的研究结果为 TBBPA 和γ辐照的毒理学提供了新的见解，凸显了 MPs 成分与放射性物质共污染的严重性，从而为受辐射损伤的水生生物和放射治疗患者提供了新的修复和康复策略。
