Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Institute for Molecular Bioscience, University of Queensland, Brisbane, Qld 4072, Australia.
Chem Commun (Camb). 2022 Nov 8;58(89):12475-12478. doi: 10.1039/d2cc05092g.
An alpha helical turn can be reproduced in a cyclic pentapeptide if the first and fifth amino acid sidechains are correctly joined. Here structural studies (CD, NMR, ) reveal why -methylation at positions not involved in hydrogen bonds disrupts helicity whereas ester bonds can maintain helicity and promote greater cell uptake.
如果第一个和第五个氨基酸侧链正确连接，环状五肽中可以重现α螺旋转角。在这里，结构研究（CD、NMR 等）揭示了为什么在不参与氢键的位置进行 -甲基化会破坏螺旋性，而酯键可以保持螺旋性并促进更大的细胞摄取。
