Neurocritical Care Clinical Pharmacist Specialist, Johns Hopkins Hospital Department of Pharmacy, Baltimore, MD, USA.
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Perfusion. 2024 Jan;39(1):223-226. doi: 10.1177/02676591221134941. Epub 2022 Oct 22.
we sought to explore the efficacy of ketamine in a patient on extracorporeal membrane oxygenation (ECMO) receiving ketamine for sedation by investigating the utility of plasma ketamine concentrations. retrospective chart review of one critically ill patient on ECMO This was a descriptive review of serial plasma ketamine concentrations in an ECMO patient. Although no reference plasma concentrations exist in ECMO patients, ketamine levels appeared to be lower than those seen in surgical patients not on ECMO. At this point, no reference plasma concentrations exist for ketamine in ECMO patients, further research may help understand the effects of ECMO on ketamine disposition and that lower ketamine concentrations may be used for effective analgesia or sedation.
我们试图通过研究血浆氯胺酮浓度来探讨体外膜氧合 (ECMO) 患者氯胺酮镇静的疗效。对 ECMO 上接受氯胺酮镇静的患者进行氯胺酮疗效的研究。这是对 ECMO 患者氯胺酮连续血浆浓度的描述性回顾。尽管在 ECMO 患者中不存在参考血浆浓度，但氯胺酮水平似乎低于非 ECMO 手术患者的水平。目前，在 ECMO 患者中没有氯胺酮的参考血浆浓度，进一步的研究可能有助于了解 ECMO 对氯胺酮处置的影响，并且较低的氯胺酮浓度可能用于有效的镇痛或镇静。
