Cerebrovascular Department, Hangzhou Third People's Hospital, Hangzhou, China.
Department of Cardiology, Hangzhou Third People's Hospital, Hangzhou, China.
Front Immunol. 2022 Oct 6;13:972536. doi: 10.3389/fimmu.2022.972536. eCollection 2022.
We studied the changes and clinical significance of the serum neuron-specific enolase (NSE) level in peripheral blood of patients with post-herpetic neuralgia (PHN).
Patients with PHN were divided into a mild PHN group and a severe PHN group according to their scores on a 100-point Likert scale representing the degree of neuralgia. NSE levels in neuralgia patients and healthy volunteers were then compared by t-test. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic efficiency of NSE for PHN. The correlation between NSE level and Likert scale score after treatment was analyzed.
NSE levels in PHN patients were higher than those in the healthy volunteers. Patients in the severe PHN group had higher NSE levels than those in the mild PHN group. NSE level at admission was associated with the Likert scale score recorded on the 14th day of treatment (136.1 ± 32.81 . 87.53 ± 16.23 pg/mL) (P < 0.05). The ROC curve of NSE levels for PHN is shown that the area was 0.8713 (95% confidence interval, 0.7861-0.9564; p < 0.0001).
There was a correlation between NSE and PHN, in that the NSE level positively correlated with the short-term prognosis of patients with PHN.
我们研究了带状疱疹后神经痛（PHN）患者外周血血清神经元特异性烯醇化酶（NSE）水平的变化及其临床意义。
根据代表神经痛程度的 100 分李克特量表评分，将 PHN 患者分为轻度 PHN 组和重度 PHN 组。然后通过 t 检验比较神经痛患者和健康志愿者的 NSE 水平。采用受试者工作特征曲线分析评估 NSE 对 PHN 的诊断效率。分析 NSE 水平与治疗后李克特量表评分的相关性。
PHN 患者的 NSE 水平高于健康志愿者。重度 PHN 组患者的 NSE 水平高于轻度 PHN 组。入院时的 NSE 水平与治疗第 14 天记录的李克特量表评分（136.1 ± 32.81. 87.53 ± 16.23 pg/mL）相关（P < 0.05）。NSE 水平对 PHN 的 ROC 曲线显示，曲线下面积为 0.8713（95%置信区间，0.7861-0.9564；p < 0.0001）。
NSE 与 PHN 之间存在相关性，NSE 水平与 PHN 患者的短期预后呈正相关。
