Strube Yi Ning J, Wright Kenneth W
Department of Ophthalmology, Queen's University / Kingston Health Sciences Centre, Kingston, ON, Canada.
Wright Foundation for Pediatric Ophthalmology and Strabismus, Los Angeles, CA, USA.
Saudi J Ophthalmol. 2022 Oct 14;36(3):239-242. doi: 10.4103/sjopt.sjopt_18_22. eCollection 2022 Jul-Sep.
Retinopathy of prematurity (ROP) is a vasoproliferative disease occurring in premature infants that affects the blood vessels of the developing retina. ROP results in the development of vascular shunts, neovascularization, and in its most severe form tractional retinal detachment. The development of retinal vascular shunts and neovascularization in ROP is related to local ischemia in the immature and incompletely vascularized retina. Understanding the pathophysiology of ROP helps physicians both in the prevention and treatment of ROP and will be discussed in this review article. The role of oxygen in the pathophysiology of ROP will be reviewed with recent studies discussed.
早产儿视网膜病变（ROP）是一种发生于早产儿的血管增殖性疾病，会影响发育中的视网膜血管。ROP会导致血管分流、新生血管形成，最严重的情况下会导致牵引性视网膜脱离。ROP中视网膜血管分流和新生血管形成与未成熟且血管化不完全的视网膜局部缺血有关。了解ROP的病理生理学有助于医生预防和治疗ROP，本文将对此进行讨论。本文将结合近期研究对氧在ROP病理生理学中的作用进行综述。
