Department of Reproductive Medicine, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
Genetic Laboratory, Maternal and Child Health Care Hospital of Baiyun District, Guangzhou, Guangdong 510010, China.
Comput Math Methods Med. 2022 Oct 14;2022:9988513. doi: 10.1155/2022/9988513. eCollection 2022.
Colorectal cancer (CRC) is a malignant tumor of the colorectal mucosa epithelial tissue transformed. The fusion of data for medical imaging has become a central issue in such biomedical applications as image-guided surgery and radiotherapy. Currently, CRC has been one of the most threatening tumors affecting people's health worldwide. The excision repair cross-complementation group 1 (ERCC1) is a key enzyme for nucleotide excision repair (NER). Emerging epidemiological studies have indicated that the presence of colorectal cancer (CRC) may be relevant to the ERCC1 rs11615 genetic polymorphism. However, the results of ERCC1 rs11615 on CRC in these studies are controversial. We searched PubMed, Web of Science, Embase, CNKI, and CBM databases for the effects of ERCC1 rs11615 variant on CRC development. There was no meta-analysis focused on the diagnosis of colorectal cancer with ERCC1 rs11615 variant. We creatively carried out a meta-analysis of nine case-control studies and used Stata (version 12.0) software to integrate the pooled odds ratios (ORs) corresponding to a 95% confidence interval (CI) of overall and subgroup analysis. Our results suggest that a significant correlation was observed between rs11615 and the susceptibility of CRC OR 95% CI = 1.13 (1.04-1.23) under an allele genetic model and OR 95% CI = 1.14 (1.01-1.30) under a dominant genetic model for overall CRC. Significant statistical difference was also noted in Asians rather than Caucasians based on the ethnicity subgroups. These results suggested that there is a certain association between rs11615 and the susceptibility of colorectal cancer in the Asian populations.
结直肠癌（CRC）是一种由结直肠黏膜上皮组织恶变形成的恶性肿瘤。医学影像数据的融合已经成为图像引导手术和放射治疗等生物医学应用中的一个核心问题。目前，CRC 已经成为全球威胁人类健康的最具威胁性的肿瘤之一。切除修复交叉互补基因 1（ERCC1）是核苷酸切除修复（NER）的关键酶。新兴的流行病学研究表明，结直肠癌（CRC）的存在可能与 ERCC1 rs11615 基因多态性有关。然而，这些研究中 ERCC1 rs11615 对 CRC 的结果存在争议。我们检索了 PubMed、Web of Science、Embase、CNKI 和 CBM 数据库，以了解 ERCC1 rs11615 变异对 CRC 发病的影响。目前尚无针对 ERCC1 rs11615 变异对结直肠癌诊断的荟萃分析。我们创新性地对 9 项病例对照研究进行了荟萃分析，并使用 Stata（版本 12.0）软件整合了总体和亚组分析中相应的汇总优势比（OR）及其 95%置信区间（CI）。我们的结果表明，在等位基因遗传模型下，rs11615 与 CRC 的易感性呈显著相关，OR95%CI=1.13（1.04-1.23）；在显性遗传模型下，OR95%CI=1.14（1.01-1.30）。基于种族亚组，亚洲人群的 OR 值比高加索人群更具有统计学意义。这些结果表明，rs11615 与亚洲人群结直肠癌的易感性之间存在一定的关联。
