IgA肾病患者中IgA1铰链区糖型的种族异质性。
Racial heterogeneity of IgA1 hinge-region -glycoforms in patients with IgA nephropathy.
作者信息
Ohyama Yukako, Yamaguchi Hisateru, Ogata Soshiro, Chiurlia Samantha, Cox Sharon N, Kouri Nikoletta-Maria, Stangou Maria J, Nakajima Kazuki, Hayashi Hiroki, Inaguma Daijo, Hasegawa Midori, Yuzawa Yukio, Tsuboi Naotake, Renfrow Matthew B, Novak Jan, Papagianni Aikaterini A, Schena Francesco P, Takahashi Kazuo
机构信息
Department of Biomedical Molecular Sciences, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
出版信息
iScience. 2022 Sep 27;25(11):105223. doi: 10.1016/j.isci.2022.105223. eCollection 2022 Nov 18.
Galactose (Gal)-deficient IgA1 (Gd-IgA1) is involved in IgA nephropathy (IgAN) pathogenesis. To reflect racial differences in clinical characteristics, we assessed disease- and race-specific heterogeneity in the -glycosylation of the IgA1 hinge region (HR). We determined serum Gd-IgA1 levels in Caucasians (healthy controls [HCs], n = 31; IgAN patients, n = 63) and Asians (HCs, n = 20; IgAN patients, n = 60) and analyzed profiles of serum IgA1 HR -glycoforms. Elevated serum Gd-IgA1 levels and reduced number of Gal residues per HR were observed in Caucasians. Reduced number of -acetylgalactosamine (GalNAc) residues per HR and elevated relative abundance of IgA1 with three HR -glycans were common features in IgAN patients; these features were associated with elevated blood pressure and reduced renal function. We speculate that the mechanisms underlying the reduced GalNAc content in IgA1 HR may be relevant to IgAN pathogenesis.
半乳糖（Gal）缺陷型IgA1（Gd-IgA1）参与IgA肾病（IgAN）的发病机制。为反映临床特征的种族差异，我们评估了IgA1铰链区（HR）O-糖基化的疾病特异性和种族特异性异质性。我们测定了白种人（健康对照[HC]，n = 31；IgAN患者，n = 63）和亚洲人（HC，n = 20；IgAN患者，n = 60）的血清Gd-IgA1水平，并分析了血清IgA1 HR O-糖型谱。在白种人中观察到血清Gd-IgA1水平升高，且每个HR的Gal残基数量减少。每个HR的N-乙酰半乳糖胺（GalNAc）残基数量减少以及具有三个HR O-聚糖的IgA1相对丰度升高是IgAN患者的共同特征；这些特征与血压升高和肾功能降低有关。我们推测IgA1 HR中GalNAc含量降低的潜在机制可能与IgAN的发病机制有关。
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