Department Of Thoracic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China.
Department of Thoracic Surgery, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing 400030, China.
Biomed Res Int. 2022 Oct 13;2022:8129771. doi: 10.1155/2022/8129771. eCollection 2022.
A large amount of publications had reported the association between incidence of esophageal cancer (EC) and type 2 diabetes mellitus (T2DM) in the past decade. However, those papers' results are inconsistent on relationships between T2DM the incidence of EC. Therefore, the objective of this meta-analysis was to determine the relationship between T2DM and the risk of EC (including 2 histological types, esophageal adenocarcinoma [EADC] and esophageal squamous cell carcinoma [ESCC]).
We finally extracted 19 articles though Pubmed, Embased, and Cochrane library. Those identify extraction date including 14,312 cases and 24,959,067 control records and then mixed the relative risks (RRs) and corresponding 95% confidence intervals (95%CIs) through STATA.
We observed that there are significantly positive correlation between T2DM and EC risk ( = 1.28, 95% CI: 1.05-1.57, = 0.015).Also, our study showed positive correlation between T2DM and EADC (esophageal adenocarcinoma) risk ( = 1.28, 95% CI: 1.05-1.57, < 0.001). What's more, subgroup analysis based on ethnicity represented the Caucasian is more susceptible to EC ( = 1.28 ,95% CI: 1.10-1.49, = 0.001).
Those results offer a recent epidemiological and integrated evidence to ascertain the correlations between T2DM and incidence of EC. Those results take public health implications on preventing T2DM and then depress the occurrence of EC. Our study also provides referenced information for the prevention. However, some data is still insufficient, and more research should be carried out.
在过去的十年中，大量出版物报道了食管癌（EC）发病率与 2 型糖尿病（T2DM）之间的关联。然而，这些论文的结果在 T2DM 与 EC 发病率之间的关系上并不一致。因此，本荟萃分析的目的是确定 T2DM 与 EC（包括食管腺癌[EADC]和食管鳞状细胞癌[ESCC]两种组织学类型）风险之间的关系。
我们最终通过 Pubmed、Embase 和 Cochrane 图书馆提取了 19 篇文章。这些文章的鉴定提取日期包括 14312 例病例和 24959067 例对照记录，然后通过 STATA 混合了相对风险（RR）和相应的 95%置信区间（95%CI）。
我们观察到 T2DM 与 EC 风险之间存在显著的正相关（RR = 1.28，95%CI：1.05-1.57， = 0.015）。此外，我们的研究还显示 T2DM 与 EADC（食管腺癌）风险之间存在正相关（RR = 1.28，95%CI：1.05-1.57， < 0.001）。更重要的是，基于种族的亚组分析表明，白种人更容易患 EC（RR = 1.28，95%CI：1.10-1.49， = 0.001）。
这些结果提供了最近的流行病学和综合证据，以确定 T2DM 与 EC 发病率之间的相关性。这些结果对预防 T2DM 进而降低 EC 的发生具有公共卫生意义。我们的研究也为预防提供了参考信息。然而，一些数据仍然不足，需要开展更多的研究。
