Baheran Sanaz Sadig, Alany Raid G, Schwikkard Sianne, Muen Wisam, Salman Lena Namaan, Freestone Nicholas, Al-Kinani Ali A
Drug Discovery, Delivery and Patient Care Research Group, School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames KT1 2EE, UK.
Drug Discovery, Delivery and Patient Care Research Group, School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames KT1 2EE, UK; School of Pharmacy, The University of Auckland, Auckland 1023, New Zealand.
Drug Discov Today. 2023 Jan;28(1):103416. doi: 10.1016/j.drudis.2022.103416. Epub 2022 Oct 22.
Pterygium is a fibrovascular tissue growth invading the cornea. Adjunctive treatment post-surgery includes conventional immunosuppressants as well as antiviral drugs. The use of large- and small-molecule antivascular endothelial growth factor (VEGF) agents remains an integral part of pterygium treatment as well as other neovascular conditions of the eye. Naturally occurring polyphenolic compounds have favorable characteristics for treating neovascular and inflammatory eye conditions, including good efficacy, stability, cost-effectiveness, and the versatility of their chemical synthesis. In this review, we discuss pharmacological treatments of pterygium. Natural products, such curcumin, ellagic acid, and chalcones, are reviewed, with emphasis on their potential as future pterygium treatments.
翼状胬肉是一种侵入角膜的纤维血管组织生长。手术后的辅助治疗包括传统免疫抑制剂以及抗病毒药物。使用大分子和小分子抗血管内皮生长因子（VEGF）药物仍然是翼状胬肉治疗以及眼部其他新生血管疾病治疗的一个组成部分。天然存在的多酚类化合物具有治疗眼部新生血管和炎症性疾病的良好特性，包括疗效好、稳定性好、成本效益高以及化学合成的多功能性。在本综述中，我们讨论翼状胬肉的药物治疗。对天然产物，如姜黄素、鞣花酸和查耳酮进行了综述，重点是它们作为未来翼状胬肉治疗方法的潜力。
