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血清甲状腺球蛋白水平低的分化型甲状腺癌伴[¹³¹I]聚集性肺和骨转移——肿瘤随访中的一个例外?

[131I-accumulating pulmonary and bone metastases of differentiated thyroid cancer with low serum thyroglobulin levels--an exception in tumor follow-up?].

作者信息

Arning G, Ehrenheim C, Schober O, Hundeshagen H

出版信息

Nuklearmedizin. 1987 Jun;26(3):139-42.

PMID:3628022
Abstract

In the follow-up of differentiated thyroid carcinoma it is discussed whether the tumor-marker thyroglobulin can replace the 131I scan, especially when the thyroglobulin serum level is normal. A positive 131I scan of metastases in the follow-up of patients with differentiated thyroid carcinoma combined with a low serum thyroglobulin level is extremely rare. The literature shows a frequency of about 4%. Recently we found 3 cases with a positive 131I scan demonstrating pulmonary and bone metastases whereas the serum thyroglobulin level was low.

摘要

在分化型甲状腺癌的随访中,人们讨论了肿瘤标志物甲状腺球蛋白是否可以取代131I扫描,尤其是当血清甲状腺球蛋白水平正常时。在分化型甲状腺癌患者的随访中,131I扫描显示转移灶阳性而血清甲状腺球蛋白水平较低的情况极为罕见。文献显示其发生率约为4%。最近我们发现了3例131I扫描阳性的病例,显示有肺和骨转移,而血清甲状腺球蛋白水平较低。

相似文献

1
[131I-accumulating pulmonary and bone metastases of differentiated thyroid cancer with low serum thyroglobulin levels--an exception in tumor follow-up?].血清甲状腺球蛋白水平低的分化型甲状腺癌伴[¹³¹I]聚集性肺和骨转移——肿瘤随访中的一个例外?
Nuklearmedizin. 1987 Jun;26(3):139-42.
2
Role of initial iodine-131 whole-body scan and serum thyroglobulin in differentiated thyroid carcinoma metastases.初始碘-131全身扫描及血清甲状腺球蛋白在分化型甲状腺癌转移中的作用
J Nucl Med. 1998 Sep;39(9):1542-6.
3
[Metastatic differentiated thyroid cancer. Diagnostic accuracy of thyroglobulin-RIA in comparison with 131I-whole body scintigraphy].[转移性分化型甲状腺癌。甲状腺球蛋白放射免疫分析与¹³¹I全身闪烁扫描诊断准确性的比较]
Rofo. 1984 Sep;141(3):306-13. doi: 10.1055/s-2008-1053138.
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Metastatic papillary thyroid carcinoma with normal serum thyroglobulin level.血清甲状腺球蛋白水平正常的转移性乳头状甲状腺癌
Clin Nucl Med. 1988 Sep;13(9):652-3. doi: 10.1097/00003072-198809000-00009.
5
The role of iodine-131 and thallium-201 imaging and serum thyroglobulin in the management of differentiated thyroid carcinoma.碘-131和铊-201成像以及血清甲状腺球蛋白在分化型甲状腺癌管理中的作用。
Cancer. 1993 Jun 1;71(11):3767-73. doi: 10.1002/1097-0142(19930601)71:11<3767::aid-cncr2820711146>3.0.co;2-w.
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Complementary role of whole body scan and serum thyroglobulin determination in the follow-up of differentiated thyroid carcinoma.全身扫描与血清甲状腺球蛋白测定在分化型甲状腺癌随访中的互补作用。
Ital J Surg Sci. 1986;16(1):11-5.
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Sustained and diffuse 131I avid bone metastases with low thyroglobulin levels in a patient with papillary thyroid carcinoma.患者患有甲状腺乳头状癌,全身骨骼 131I 摄取弥漫且活跃,但甲状腺球蛋白水平低。
Clin Nucl Med. 2013 May;38(5):375-7. doi: 10.1097/RLU.0b013e31828682a4.
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Thyroglobulin radioimmunoassay and 131I scintigraphy in patients with differentiated thyroid carcinoma.分化型甲状腺癌患者的甲状腺球蛋白放射免疫分析及¹³¹I闪烁扫描术
Acta Chir Scand. 1988 Feb;154(2):141-5.
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Serum thyroglobulin and iodine-131 whole-body scan in the diagnosis and assessment of treatment for metastatic differentiated thyroid carcinoma.血清甲状腺球蛋白及碘-131全身扫描在转移性分化型甲状腺癌的诊断及治疗评估中的应用
J Nucl Med. 1994 Feb;35(2):257-62.
10
[Follow-up of patients with differentiated thyroid cancer: determination of serum thyroglobulin in place of routine 131I scintigraphy?].[分化型甲状腺癌患者的随访:用血清甲状腺球蛋白测定替代常规131I闪烁扫描?]
Wien Klin Wochenschr. 1984 May 11;96(10):389-93.

引用本文的文献

1
Value of 111In-DOTA-lanreotide and 111In-DOTA-DPhe1-Tyr3-octreotide in differentiated thyroid cancer: results of in vitro binding studies and in vivo comparison with 18F-FDG PET.111铟标记的DOTA-兰瑞肽和111铟标记的DOTA-DPhe1-Tyr3-奥曲肽在分化型甲状腺癌中的价值:体外结合研究结果及与18F-FDG PET的体内比较
Eur J Nucl Med Mol Imaging. 2005 Oct;32(10):1144-51. doi: 10.1007/s00259-005-1820-1. Epub 2005 May 21.
2
Low levels of serum thyroglobulin after withdrawal of thyroid suppression therapy in the follow up of differentiated thyroid carcinoma.分化型甲状腺癌随访中甲状腺抑制治疗停药后血清甲状腺球蛋白水平较低。
Eur J Nucl Med. 1990;16(1):35-8. doi: 10.1007/BF01566010.