Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Avda. Cataluña, 21, 46020 Valencia, Spain.
Vaccines Research Unit, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Avda. Cataluña, 21, 46020 Valencia, Spain; Universidad Católica de Valencia San Vicente Mártir, Carrer de Quevedo, 2, 46001 València, Spain.
Vaccine. 2022 Nov 8;40(47):6711-6721. doi: 10.1016/j.vaccine.2022.09.096. Epub 2022 Oct 22.
Previous studies found conflicting results about the effect of rotavirus (RV) vaccination on seizure hospitalizations in children younger than 5 years old.
To evaluate the evidence of the impact of RV vaccination on the prevention of seizure hospitalizations in children.
A systematic review was conducted in the electronic database MEDLINE of all observational studies in children younger than 5 years old published since 2006. Two reviewers performed title/abstract, full-text review, and data extraction.
Thirteen studies met eligibility criteria. Nine studies reported a significant reduction in seizure hospitalizations upon RV vaccine introduction, three studies reported an absence of significant impact, and one study reported a significant rise in seizure hospitalization after the introduction of RV vaccines.
The great variability between study designs, case definitions and potential biases prevent quantifying the impact of RV vaccination against seizure hospitalizations.
RV vaccination might prevent seizure hospitalizations in children; however, robust, and well-designed studies are needed to better determine the strength of this association.
此前的研究对轮状病毒 (RV) 疫苗接种对 5 岁以下儿童癫痫住院的影响得出了相互矛盾的结果。
评估 RV 疫苗接种对预防儿童癫痫住院的效果的证据。
对 2006 年以来发表的所有针对 5 岁以下儿童的观察性研究，在电子数据库 MEDLINE 中进行了系统综述。两名审查员进行了标题/摘要、全文审查和数据提取。
13 项研究符合入选标准。9 项研究报告 RV 疫苗接种后癫痫住院率显著降低，3 项研究报告无显著影响，1 项研究报告 RV 疫苗接种后癫痫住院率显著升高。
研究设计、病例定义和潜在偏倚的巨大差异使得难以量化 RV 疫苗接种对癫痫住院的影响。
RV 疫苗接种可能预防儿童癫痫住院；然而，需要进行稳健且精心设计的研究，以更好地确定这种关联的强度。
