Faarup P, Nørgaard T, Elling F, Jensen H
Acta Pathol Microbiol Scand A. 1978 Sep;86A(5):409-14. doi: 10.1111/j.1699-0463.1978.tb02065.x.
Structural changes in kidney biopsies were investigated from five patients with primary oliguric extracapillary glomerulonephritis in whom the renal function was adequately maintained during extended combined immunosuppressive treatment. The most important structural change was a pronounced decrease in the number of crescents. Reduction in numbers of crescents in the late biopsies was significantly greater than the increase in the number of hyalinized glomeruli. Tubular parenchyma showed only slight diffuse atrophy, and a moderate interstitial fibrosis was always present during the latter stages of treatment. Disappearance of crescents in the glomeruli was not accompanied by disappearance of immunoglobulins. Successfull immunosuppressive treatment of extracapillary glomerulonephritis causes the disappearance of structural characteristics of the kidney that are diagnostic for this disease.
对5例原发性少尿型毛细血管外肾小球肾炎患者的肾活检结构变化进行了研究，这些患者在长期联合免疫抑制治疗期间肾功能得到了充分维持。最重要的结构变化是新月体数量显著减少。晚期活检中新月体数量的减少明显大于玻璃样变性肾小球数量的增加。肾小管实质仅表现为轻度弥漫性萎缩，治疗后期始终存在中度间质纤维化。肾小球中新月体的消失并未伴随免疫球蛋白的消失。成功的毛细血管外肾小球肾炎免疫抑制治疗导致了对该疾病具有诊断意义的肾脏结构特征的消失。
