Modeling the spatio‑temporal spread of COVID‑19 cases, recoveries and deaths and effects of partial and full vaccination coverage in Canada.

The purposes of our study are to map high-risk areas in Canada as well as quantifying the effects of vaccination intervention and socio-demographic factors on the transmission rates of infection, recovery, and death related to COVID-19. The data of this research included weekly number of COVID‑19 cases, recovered, and dead individuals from 2020 through 2021 in Canada at health region and provincial levels. These data were associated with cumulative rates of partial and full vaccination and socio-demographic factors. We applied the spatio-temporal Susceptible-Exposed-Infected-Removed (SEIR), and Susceptible-Exposed-Infected-Removed-Vaccinated (SEIRV) models. The results indicated the partial vaccination rate has a greater effect compared with full vaccination rate on decreasing the rate of infectious cases (risk ratio (RR) = 0.18; 95%CrI: 0.16-0.2; RR = 0.60; 95%CrI: 0.55-0.65, respectively) and increasing the rate of recovered cases (RR = 1.39; 95%CrI: 1.28-1.51; RR = 1.21; 95%CrI: 1.23-1.29, respectively). However, for mortality risk reduction, only increasing full vaccination rate was significantly associated (RR = 0.09; 95%CrI: 0.05-0.14). In addition, our results showed that regions with higher rates of elderly and aboriginal individuals, higher population density, and lower socioeconomic status (SES) contribute more to the risk of infection transmission. Rates of elderly and aboriginal individuals and SES of regions were significantly associated with recovery rate. However, elderly individuals rate of regions was only a significant predictor of mortality risk. Based on the results, protection against mild and severe COVID-19 infection after the primary vaccination series decreased.