Department of Neurology, Medical School, Medeniyet University, Istanbul Turkey.
Department of Psychiatry, Medical School, Istanbul Medeniyet University, Istanbul, Turkey.
J Pak Med Assoc. 2022 Aug;72(8):1656-1658. doi: 10.47391/JPMA.4480.
Limbic encephalitis (LE), a rare cause of encephalitis, generally presents with neuropsychiatric manifestations, memory deficits, seizures, and movement disorders. The case of a 41-year-old female patient with LE involving the left amygdala is presented. The patient was admitted to the emergency department with complaints of unconsciousness and seizures. Paraneoplastic and limbic markers were negative. This case was diagnosed as seronegative LE. Three to four months after the diagnosis, it was observed that her sexual preference changed to the female sex. No report has been published so far, concerning any case of LE associated with changes in sexual behaviour. The patient was treated with intravenous methylprednisolone (IVP) and triple antiepileptic therapy. After treatment, changes in sexual behaviour returned to the previous state.
边缘性脑炎（LE）是一种罕见的脑炎病因，通常表现为神经精神症状、记忆障碍、癫痫发作和运动障碍。本文报告了一例累及左侧杏仁核的 41 岁女性 LE 患者。患者因意识丧失和癫痫发作被收入急诊病房。副肿瘤和边缘标志物均为阴性。该病例被诊断为血清阴性 LE。诊断后 3-4 个月，观察到她的性取向变为女性。目前尚未有任何关于 LE 与性行为改变相关的病例报告。患者接受了静脉注射甲基强的松龙（IVP）和三联抗癫痫治疗。治疗后，性行为的改变恢复到之前的状态。
