Orthopedics Center of PLA, The 940th Hospital of Joint Logistics Support Force Army of PLA, Lanzhou, China.
Department of Orthopedics, The Third People's Hospital, Baiyin, China.
Medicine (Baltimore). 2022 Oct 21;101(42):e31260. doi: 10.1097/MD.0000000000031260.
Rotator cuff tears are one of the most common injuries of the shoulder joint in adults. Arthroscopic rotator cuff repair (ARCR) has become the gold standard for the treatment of rotator cuff injuries, but it still has a high rate of retear. Platelet-rich plasma (PRP) has been widely used as an adjunct to ARCR. However, the comparative efficacy of different PRP for ARCR remain unclear. In order to evaluate the relative efficacy of PRP for individuals with ARCR, we will conduct a systematic review and network meta-analysis of randomized controlled trials.
A systematic literature search will be conducted in Embase, PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, and Chinese Biomedical Literature Database will be searched up to October 2022. The primary outcome will focus on the retear rate at the last follow-up. The secondary outcomes include the Visual Analogue Scale for postoperative pain and functional capacity scores. The risk of bias for individual studies will be assessed according to the revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0). Data analysis will be performed using R 4.1.2. Publication bias will be examined using comparison-adjusted funnel plots and Egger's test using STATA 15.0. The quality of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach.
The results of this study will be submitted to a peer-reviewed journal for publication.
The review will compare the efficacy of different PRP for patients with ARCR. The result of the study will provide evidence-based medical evidence for ARCR with PRP augmentation.
肩袖撕裂是成年人肩关节最常见的损伤之一。关节镜下肩袖修复术（ARCR）已成为肩袖损伤治疗的金标准，但仍有很高的再撕裂率。富血小板血浆（PRP）已广泛应用于 ARCR 的辅助治疗。然而，不同 PRP 用于 ARCR 的疗效比较尚不清楚。为了评估 PRP 对 ARCR 个体的相对疗效，我们将对随机对照试验进行系统评价和网络荟萃分析。
我们将在 Embase、PubMed、Cochrane 图书馆、Web of Science、中国知网、万方数据库和中国生物医学文献数据库中进行系统文献检索，检索时间截至 2022 年 10 月。主要结局将集中在末次随访时的再撕裂率。次要结局包括术后疼痛的视觉模拟量表和功能能力评分。将根据改良 Cochrane 随机试验偏倚风险工具（RoB 2.0）评估单个研究的偏倚风险。使用 R 4.1.2 进行数据分析。使用 STATA 15.0 通过比较调整的漏斗图和 Egger 检验来检查发表偏倚。使用推荐、评估、制定和评估方法评估证据质量。
本研究的结果将提交给同行评议期刊发表。
该综述将比较不同 PRP 治疗 ARCR 患者的疗效。该研究的结果将为 PRP 增强的 ARCR 提供循证医学证据。
