Department of Anesthesiology, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu, PR China.
Department of Respiratory, Zhejiang Hospital, 12 Lingyin Road, West Lake District, Hangzhou, Zhejiang, PR China.
Medicine (Baltimore). 2022 Oct 21;101(42):e31258. doi: 10.1097/MD.0000000000031258.
To investigate the influence of continuous positive airway pressure (CPAP) on lipid profiles of the patients with obstructive sleep apnea (OSA) in this meta-analysis.
Relevant studies reporting the correlation between CPAP and lipid profiles of OSA patients were searched in Pubmed, Cochrane Library and Embase before January 1, 2021. Data of eligible studies were extracted and analyzed using the fixed-effect or random-effect model. Standard mean difference (SMD) and 95% confidence interval (95% CI) were calculated to assess such influence. Subgroup analysis based on CPAP duration was further performed. STATA 12.0 was used in this meta-analysis.
A total of 12 independent randomized controlled studies involved 1129 OSA patients were recruited in this meta-analysis. The analyzed lipid profiles included total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL). CPAP was not correlated to TC (SMD = -0.07, 95% CI = -0.33 to 0.19), TG (SMD = -0.01, 95% CI = -0.19 to 0.17), LDL (SMD = -0.01, 95% CI = -0.23 to 0.21) and HDL (SMD = 0.10, 95% CI = -0.03 to 0.22) in OSA patients. Moreover, CPAP duration (=12 weeks; >12 weeks; <12 weeks) also did not influence lipid profiles of OSA patients as well.
Regardless of the treatment in CPAP duration, it doses does not influence lipid profiles of OSA patients, including TC, TG, LDL and HDL. The results are inconsistent with previous findings, which should be further validated in the multi-center, long-term randomized controlled trials.
本荟萃分析旨在探讨持续气道正压通气（CPAP）对阻塞性睡眠呼吸暂停（OSA）患者血脂谱的影响。
在 2021 年 1 月 1 日之前，检索 Pubmed、Cochrane 图书馆和 Embase 中有关 CPAP 与 OSA 患者血脂谱相关性的研究。提取合格研究的数据，并使用固定效应或随机效应模型进行分析。采用标准均数差（SMD）和 95%置信区间（95%CI）评估这种影响。进一步进行基于 CPAP 持续时间的亚组分析。本荟萃分析使用 STATA 12.0 进行。
本荟萃分析共纳入 12 项独立的随机对照研究，共纳入 1129 例 OSA 患者。分析的血脂谱包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。CPAP 与 TC（SMD=-0.07，95%CI=-0.33 至 0.19）、TG（SMD=-0.01，95%CI=-0.19 至 0.17）、LDL（SMD=-0.01，95%CI=-0.23 至 0.21）和 HDL（SMD=0.10，95%CI=-0.03 至 0.22）均无相关性。此外，CPAP 持续时间（=12 周；>12 周；<12 周）也未影响 OSA 患者的血脂谱。
无论 CPAP 持续时间如何，CPAP 对 OSA 患者的血脂谱（包括 TC、TG、LDL 和 HDL）均无影响。这一结果与之前的研究结果不一致，需要在多中心、长期的随机对照试验中进一步验证。
