Takeshi Tanigawa, MD, PhD, Department of Public Health, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Phone: +81 (3) 5802-1049 Fax: +81 (3) 3814-0305, Email:
J Prev Alzheimers Dis. 2022;9(4):752-757. doi: 10.14283/jpad.2022.51.
There is growing interest in examining objective markers for early identification and behavioral intervention to prevent dementia and mild cognitive impairment in clinical and community settings.
To investigate the association between salivary alpha-amylase as an objective measure of psychological stress response and mild cognitive impairment for the implication of psychological stress in the development of mild cognitive impairment.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study involved 865 participants aged ≥ 65 years. A saliva sample was collected in the morning, and the levels of salivary alpha-amylase were assayed. Mild cognitive impairment was evaluated using the Japanese version of the Montreal Cognitive Assessment; a score < 26 was indicative of mild cognitive impairment. A multivariable logistic regression model was used to examine the association of salivary alpha-amylase and mild cognitive impairment after adjusting for age, sex, current drinking status, current smoking status, body mass index, hypertension, diabetes mellitus, physical activity, education, social support, social network, and heart rate variability.
Salivary alpha-amylase was associated with mild cognitive impairment (the multivariable-adjusted odds ratio [95% confidence interval] for the 1-standard deviation increment of log-transformed salivary alpha-amylase was 1.24 [1.07-1.44]). This significant association persisted after adjusting for various confounding factors.
Elevation of salivary alpha-amylase was associated with mild cognitive impairment among Japanese community-dwelling older adults. This suggests that salivary alpha-amylase is a useful objective marker of psychological stress responses associated with mild cognitive impairment.
人们越来越关注在临床和社区环境中寻找客观标志物，以早期识别和实施行为干预，从而预防痴呆和轻度认知障碍。
探究唾液淀粉酶作为心理应激反应的客观指标与轻度认知障碍之间的关系，以探讨心理应激在轻度认知障碍发展中的作用。
设计、地点和参与者：本横断面研究纳入了 865 名年龄≥65 岁的参与者。清晨采集唾液样本并检测唾液淀粉酶水平。采用日本版蒙特利尔认知评估量表评估轻度认知障碍，评分<26 分提示存在轻度认知障碍。采用多变量逻辑回归模型，在调整年龄、性别、当前饮酒状态、当前吸烟状态、体重指数、高血压、糖尿病、身体活动、教育、社会支持、社会网络和心率变异性等因素后，分析唾液淀粉酶与轻度认知障碍之间的关系。
唾液淀粉酶与轻度认知障碍相关（log 转化后唾液淀粉酶每增加 1 个标准差，多变量调整后的优势比[95%置信区间]为 1.24[1.07-1.44]）。在调整各种混杂因素后，这种显著关联仍然存在。
日本社区居住的老年人群中，唾液淀粉酶水平升高与轻度认知障碍相关。这表明唾液淀粉酶是与轻度认知障碍相关的心理应激反应的有用客观标志物。
