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Chilblains outbreak during COVID-19 pandemic: A Type-I interferonopathy?

作者信息

Mensa-Vilaró Anna, Vicente Asunción, Español-Rego Marta, Antón Jordi, Fabregat Virginia, Fortuny Claudia, González Europa Azucena, Fumadó Victoria, González-Roca Eva, Jou Cristina, Plaza Susana, Mosquera Juan Manuel, Yagüe Jordi, Prat Carolina, Pascal Mariona, Juan Manel, Arostegui Juan I, Baselga Eulalia, Alsina Laia

机构信息

Department of Immunology, Hospital Clínic, Barcelona, Spain.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.

出版信息

Pediatr Allergy Immunol. 2022 Oct;33(10):e13860. doi: 10.1111/pai.13860.

DOI:10.1111/pai.13860
PMID:36282139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9874765/
Abstract
摘要

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Biomarkers of Endothelial Damage in Distinct Phases of Multisystem Inflammatory Syndrome in Children.儿童多系统炎症综合征不同阶段内皮损伤的生物标志物
Metabolites. 2022 Jul 24;12(8):680. doi: 10.3390/metabo12080680.
2
Lack of association between pandemic chilblains and SARS-CoV-2 infection.大流行性寒冷性红斑与 SARS-CoV-2 感染之间缺乏关联。
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2122090119.
3
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19.儿童多系统炎症综合征和儿童 COVID-19 的免疫病理特征。
Nat Med. 2022 May;28(5):1050-1062. doi: 10.1038/s41591-022-01724-3. Epub 2022 Feb 17.
4
Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak.COVID-19 疫情期间冻疮样皮损中的 I 型干扰素反应和血管改变。
Br J Dermatol. 2021 Dec;185(6):1176-1185. doi: 10.1111/bjd.20707. Epub 2021 Oct 5.
5
Autoantibodies neutralizing type I IFNs are present in 4% of uninfected individuals over 70 years old and account for 20% of COVID-19 deaths.在 70 岁以上未感染的人群中，有 4%存在中和 I 型干扰素的自身抗体，占 COVID-19 死亡人数的 20%。
Sci Immunol. 2021 Aug 19;6(62). doi: 10.1126/sciimmunol.abl4340.
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IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19.IP-10 和 MCP-1 作为与 COVID-19 疾病严重程度相关的生物标志物。
Mol Med. 2020 Oct 29;26(1):97. doi: 10.1186/s10020-020-00230-x.
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No SARS-CoV-2 antibody response in 25 patients with pseudo-chilblains.25 例假性冻疮患者均未出现 SARS-CoV-2 抗体应答。
Dermatol Ther. 2020 Nov;33(6):e14332. doi: 10.1111/dth.14332. Epub 2020 Oct 5.
8
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.COVID-19 危重症患者体内针对 I 型干扰素的自身抗体。
Science. 2020 Oct 23;370(6515). doi: 10.1126/science.abd4585. Epub 2020 Sep 24.
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Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein.皮肤冻疮样病变中抗SARS-CoV-2刺突蛋白与RNA染色不一致，提示裂解的刺突蛋白在内皮沉积。
J Cutan Pathol. 2021 Jan;48(1):47-52. doi: 10.1111/cup.13866. Epub 2020 Oct 1.
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.严重 COVID-19 患者的 I 型干扰素活性和炎症反应受损。
Science. 2020 Aug 7;369(6504):718-724. doi: 10.1126/science.abc6027. Epub 2020 Jul 13.