Qi Jing, Liu Huijuan, Wang Limin, Chen Ying, Fu Jiahui, Zheng Huanwei, Wang Chunya, Chen Jing, Wang Ruifang, Zhao Pan
Department of Disease Control and Prevention, Southern Medical Branch, Chinese PLA General Hospital, Beijing, 100071, China.
Neonatal Unit, Fifth Medical Center (Formerly Beijing 302 Hospital), Chinese PLA General Hospital, Beijing, 100039, China.
Infect Dis Ther. 2022 Dec;11(6):2233-2240. doi: 10.1007/s40121-022-00704-x. Epub 2022 Oct 25.
There is a need for data to evaluate hepatitis B antigenemia in newborns of mothers with hepatitis B virus (HBV) infection. This study aims to investigate this.
Newborns with positive serum hepatitis B surface antigen (HBsAg) and/or e antigen (HBeAg) were enrolled in the study.
One hundred and one newborns from 98 HBV-infected mothers were included. Median maternal serum HBV DNA level was 23,200 IU/mL at delivery. Among the newborns, 48 were boys and 53 were girls. Mean birth weight was 3190.5 g. Twenty-one newborns had concurrent seropositive HBsAg and HBeAg, nine had seropositive HBsAg and seronegative HBeAg, and 71 had seronegative HBsAg and seropositive HBeAg. Eight newborns had detectable serum HBV DNA. In the follow-up, serum HBsAg and HBeAg in the newborns with undetectable HBV DNA became negative before 6 months of age. Two infants with detectable HBV DNA were diagnosed with immunoprophylaxis failure, one of whom developed active hepatitis at 3 months of age. Liver biopsy in this case showed significant interface hepatitis, fibrous septa formation, and expansion of portal areas with occasional bridging fibrosis.
Concurrent HBV viremia and antigenemia in newborns of HBV-infected mothers requires attention, while antigenemia without viremia is often transient.
需要数据来评估感染乙型肝炎病毒（HBV）的母亲所生新生儿的乙型肝炎抗原血症。本研究旨在对此进行调查。
血清乙型肝炎表面抗原（HBsAg）和/或e抗原（HBeAg）呈阳性的新生儿被纳入研究。
纳入了98名感染HBV母亲的101名新生儿。分娩时母亲血清HBV DNA水平中位数为23,200 IU/mL。新生儿中，48名是男孩，53名是女孩。平均出生体重为3190.5 g。21名新生儿同时HBsAg和HBeAg血清学阳性，9名HBsAg血清学阳性且HBeAg血清学阴性，71名HBsAg血清学阴性且HBeAg血清学阳性。8名新生儿血清HBV DNA可检测到。在随访中，HBV DNA检测不到的新生儿血清HBsAg和HBeAg在6个月龄前转阴。2名HBV DNA可检测到的婴儿被诊断为免疫预防失败，其中1名在3个月龄时发生了活动性肝炎。该病例的肝活检显示有明显的界面性肝炎、纤维间隔形成以及门管区扩大，偶尔有桥接纤维化。
感染HBV的母亲所生新生儿中同时存在HBV病毒血症和抗原血症需要引起关注，而无病毒血症的抗原血症通常是短暂的。
