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局部麻醉下的上呼吸道多水平射频治疗可提高重度阻塞性睡眠呼吸暂停(OSA)患者对 CPAP 的依从性。

Upper airway multilevel radiofrequency under local anesthesia can improve CPAP adherence for severe OSA patients.

机构信息

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Benha University, Benha, Egypt.

出版信息

Am J Otolaryngol. 2023 Jan-Feb;44(1):103671. doi: 10.1016/j.amjoto.2022.103671. Epub 2022 Oct 20.

Abstract

OBJECTIVE

To evaluate the effect of upper airway radiofrequency (RF) tissue reduction under local anesthesia (LA) in severe obstructive sleep apnea (OSA) patients using continuous positive airway pressure (CPAP) in order to improve their compliance and adherence.

DESIGN

Thirty (30) patients were included in this randomized clinical trial, suffering from severe OSA seeking medical advice for better upper airway management while using CPAP. Multilevel RF tissue reduction at tongue base, soft palate and inferior nasal turbinates was done under LA in multiple sessions. The Apnea hypopnea index (AHI), arousal index, lowest SpO2, CPAP pressure, and CPAP using time were recorded pre-operatively and six months after the last RF session.

RESULTS

Post-operatively, there were significant reduction in AHI (86.03 ± 20.5 vs. 54.65 ± 16.6 p < 0.001), arousal index (71.14 ± 17.7 vs. 35.90 ± 11.8 p < 0.001), and CPAP Pressure (17.13 ± 1.7 vs. 10.97 ± 1.5 p < 0.001). Also there was a significant increase in the lowest SpO2 (60.2 ± 0.2 vs. 75 ± 0.1 p < 0.001), and CPAP using time in hours (1.57 ± 0.56 vs. 3.75 ± 0.41 p < 0.001). Visual analogue scale (VAS) for pain was recorded showing that all patients reported throat pain mainly in the first five post-operative days which was well controlled on analgesia.

CONCLUSION AND RELEVANCE

Upper airway multilevel RF tissue reduction of tongue base, soft palate and inferior nasal turbinates under local anesthesia significantly improves the tolerance and adherence of severe OSA patients using CPAP.

摘要

目的

评估在持续气道正压通气(CPAP)治疗下,局部麻醉(LA)下对上气道射频(RF)组织减少对严重阻塞性睡眠呼吸暂停(OSA)患者的影响,以提高他们的依从性。

设计

30 例严重 OSA 患者纳入本随机临床试验,在使用 CPAP 寻求更好的上气道管理建议时出现严重 OSA,接受多水平 RF 舌基底、软腭和下鼻甲组织减少术。在多次治疗中进行 LA 下的多水平 RF 组织减少术。在术前和最后一次 RF 治疗后 6 个月记录呼吸暂停低通气指数(AHI)、觉醒指数、最低 SpO2、CPAP 压力和 CPAP 使用时间。

结果

术后 AHI(86.03±20.5 与 54.65±16.6,p<0.001)、觉醒指数(71.14±17.7 与 35.90±11.8,p<0.001)和 CPAP 压力(17.13±1.7 与 10.97±1.5,p<0.001)均显著降低。最低 SpO2(60.2±0.2 与 75±0.1,p<0.001)和 CPAP 使用时间(1.57±0.56 与 3.75±0.41,p<0.001)均显著增加。疼痛视觉模拟评分(VAS)显示,所有患者均报告术后 5 天内主要出现喉咙疼痛,经止痛治疗后得到良好控制。

结论和相关性

在 LA 下对上气道多水平 RF 组织减少术显著提高了严重 OSA 患者对 CPAP 的耐受性和依从性。

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