D'Allesandro B, Esposito V, Lo Iudice G, Cagnoni M, Tarquini B
Prog Clin Biol Res. 1987;227B:281-4.
The 4-hr sampling schedule for a single day demonstrated a prominent circadian rhythm of prolactin (PRL) in clinically healthy women and in mastopathy (FM) patients (with mesor hyperprolactinemia). This chapter reports on differences in time series of serum PRL observed between FM patients and healthy women in the follicular and luteal phases. Thirteen FM patients and six healthy women (controls) were sampled at intervals of 60 min for 24 hr in the two phases of the menstrual cycle. Serum PRL was determined by RIA. The results from spectral analysis of these data showed prominent circadian rhythms and an ultradian (12-hr) significant component in the PRL of controls and FM patients in both phases of the menstrual cycle. The acrophases of the 12-hr rhythms, however, clearly differed in controls and FM patients.
单日4小时采样时间表显示，在临床健康女性和乳腺病（FM）患者（伴有平均催乳素血症）中，催乳素（PRL）存在显著的昼夜节律。本章报告了在卵泡期和黄体期，FM患者与健康女性血清PRL时间序列的差异。在月经周期的两个阶段，对13名FM患者和6名健康女性（对照组）进行了24小时的采样，采样间隔为60分钟。采用放射免疫分析法测定血清PRL。这些数据的频谱分析结果显示，在月经周期的两个阶段，对照组和FM患者的PRL均存在显著的昼夜节律和超昼夜（12小时）显著成分。然而，对照组和FM患者12小时节律的峰相位明显不同。
