Singh R K, Singh S, Razdan J L
Prog Clin Biol Res. 1987;227B:335-42.
Circadian periodicity of plasma 17-hydroxycorticosteroids (17-OHCS) was studied in ten patients with advanced breast cancer and ten healthy volunteers. A marked rhythm in plasma 17-OHCS concentration was noticed in normal controls; the maximum concentration occurred at 0800 hr followed by a consistent decline throughout the daytime, reaching a minimum at 0000 hr. The circadian rhythm of plasma 17-OHCS was found to be deranged in six of the patients with breast cancer, but a normal rhythmic pattern was seen in the remaining four patients, although the values remained elevated at all time points of the 24-hr cycle in the patients with breast cancer compared to the healthy volunteers. The normal and altered plasma 17-OHCS rhythms in the patients presumably could be due to individual susceptibility and response to the pathophysiological stress of cancer.
对10例晚期乳腺癌患者和10名健康志愿者的血浆17 - 羟皮质类固醇（17 - OHCS）昼夜节律进行了研究。在正常对照组中观察到血浆17 - OHCS浓度有明显的节律；最高浓度出现在08:00，随后在白天持续下降，在00:00达到最低。发现6例乳腺癌患者血浆17 - OHCS的昼夜节律紊乱，但其余4例患者呈现正常的节律模式，不过与健康志愿者相比，乳腺癌患者24小时周期内所有时间点的数值均保持升高。患者血浆17 - OHCS节律正常和改变可能是由于个体对癌症病理生理应激的易感性和反应不同。
