Chen Tingting, Wang Yuzhu, Tian Dan, Zhang Jieqing, Xu Qing, Lv Qianzhou, Li Xiaoyu, Wang Jina
Department of Pharmacy, ZhongShan Hospital, Fudan University, Shanghai, People's Republic of China.
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.
Patient Prefer Adherence. 2022 Oct 19;16:2811-2819. doi: 10.2147/PPA.S383243. eCollection 2022.
Follow-up and immunosuppressive medication (ISM) adherence are both important for kidney transplant recipients postoperatively and whether follow-up factors affect the ISM adherence remains unclear. The aim of this study was to examine the relationship between follow-up factors and ISM adherence, and the factors associated with ISM adherence.
An internet-based cross-sectional survey was conducted in a single kidney transplant center in China. The participants completed the internet-based questionnaire and the Basel Assessment of Adherence to Immunosuppressive Medication Scale (BAASIS©) from January 12 to January 26, 2021.
Finally, 288 (66.7%) participants responded to this survey. The percentage of full adherence to immunosuppressant was 51.7% (149/288), with 33.3% of the participants reporting a problem in timing dimension. We found that follow-up with a fixed doctor was significantly positive to good adherence (OR=2.124, 95% CI=1.111-4.062, =0.023) after analyzing the survey data. Time since kidney transplantation and number of non-immunosuppressants were both associated with immunosuppressant adherence. No significant difference was found regarding the effect of the follow-up adherence on ISM adherence.
Our study demonstrated an insufficient prevalence of adherence to immunosuppressant in Chinese renal transplant recipients and revealed that follow-up with a fixed doctor may be a way to improve the patients' ISM adherence. This anonymous internet-based survey provides valuable insight into the actual adherence rate, factors associated with non-adherence, and situations that may improve medication-taking.
随访和免疫抑制药物（ISM）依从性对肾移植受者术后均很重要，而随访因素是否影响ISM依从性尚不清楚。本研究旨在探讨随访因素与ISM依从性之间的关系以及与ISM依从性相关的因素。
在中国一家单一的肾移植中心进行了一项基于互联网的横断面调查。参与者于2021年1月12日至1月26日完成了基于互联网的问卷以及巴塞尔免疫抑制药物依从性评估量表（BAASIS©）。
最终，288名（66.7%）参与者回复了该调查。免疫抑制剂完全依从率为51.7%（149/288），33.3%的参与者报告在时间维度上存在问题。在分析调查数据后，我们发现固定医生随访与良好依从性呈显著正相关（OR=2.124，95%CI=1.111-4.062，P=0.023）。肾移植后的时间和非免疫抑制剂的数量均与免疫抑制剂依从性相关。随访依从性对ISM依从性的影响未发现显著差异。
我们的研究表明中国肾移植受者中免疫抑制剂依从性普遍不足，并揭示固定医生随访可能是提高患者ISM依从性的一种方式。这项基于互联网的匿名调查为实际依从率、与不依从相关的因素以及可能改善服药情况提供了有价值的见解。
