采用巴塞尔免疫抑制药物依从性评估量表进行横断面研究评估中国肾移植受者对免疫抑制药物的认知
Beliefs of Immunosuppressive Medication Among Chinese Renal Transplant Recipients, as Assessed in a Cross-Sectional Study With the Basel Assessment of Adherence to Immunosuppressive Medications Scale.
作者信息
Xia M, Yan J, Liu S, Liu J
机构信息
The Third Affiliated Hospital, Central South University, Changsha, Hunan, China.
The Third Affiliated Hospital, Central South University, Changsha, Hunan, China; Nursing School of Central South University, Changsha, Hunan, China; Research Center of Chinese Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China.
出版信息
Transplant Proc. 2019 Apr;51(3):742-748. doi: 10.1016/j.transproceed.2018.10.029. Epub 2019 Jan 10.
BACKGROUND
Adherence to immunosuppressive medication (IM) after renal transplantation is crucial to survival of patient and graft outcomes; whether beliefs about IM adherence and other sociodemographic factors affect IM adherence is debatable.
OBJECTIVE
This study aimed to examine the beliefs on IM and IM adherence in Chinese renal transplant recipients.
METHODS
Across-sectional survey was conducted. Self-developed IM beliefs questionnaire guided by health belief model was used to measure IM beliefs. The Basel Assessment of Adherence to Immunosuppressive Medications Scale was used to assess drug adherence.
RESULTS
The nonadherence rate to IM in 208 renal transplant recipients during outpatient follow-up was 44.2%. There were statistically significant associations between adherence and the marital status (P < .001). Perceived seriousness of not taking IM (P < .001) and perceived barriers of taking IM (P < .001) were significantly associated with IM adherence. After controlling other factors, married marital status, high levels of perceived seriousness of not taking IM, and lower levels of perceived barriers of taking IM (P = .007) were significantly associated with IM adherence.
CONCLUSION
Marital status and IM beliefs are closely association with IM adherence in Chinese renal transplant recipients.
背景
肾移植后坚持服用免疫抑制药物（IM）对于患者的生存和移植肾结局至关重要；关于IM依从性的信念以及其他社会人口学因素是否会影响IM依从性仍存在争议。
目的
本研究旨在调查中国肾移植受者对IM的信念及IM依从性。
方法
进行了一项横断面调查。采用以健康信念模型为指导自行编制的IM信念问卷来测量IM信念。使用巴塞尔免疫抑制药物依从性评估量表来评估药物依从性。
结果
208例肾移植受者门诊随访期间IM的不依从率为44.2%。依从性与婚姻状况之间存在统计学显著关联（P <.001）。未服用IM的感知严重性（P <.001）和服用IM的感知障碍（P <.001）与IM依从性显著相关。在控制其他因素后，已婚婚姻状况、未服用IM的高感知严重性水平以及服用IM的低感知障碍水平（P =.007）与IM依从性显著相关。
结论
婚姻状况和IM信念与中国肾移植受者的IM依从性密切相关。
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