Okamoto Soichiro, Matsui Yusuke, Hiraki Takao, Iguchi Toshihiro, Tomita Koji, Uka Mayu, Gobara Hideo, Kanazawa Susumu
Department of Radiology, Okayama University Medical School, Okayama, Japan.
Interv Radiol (Higashimatsuyama). 2020 May 14;5(2):77-81. doi: 10.22575/interventionalradiology.2019-0014. eCollection 2020 Jun 30.
We describe three cases of renal cell carcinoma (RCC) with recurring local tumor progression, i.e., local failure following repeat cryoablation for a locally progressed tumor. A second local progression developed in all cases after cryoablation for the first local progression, despite there being a sufficiently large ice-ball margin. In two cases, the second local progression was treated with microwave ablation and controlled in the follow-up. In one case, a third cryoablation was performed, but a third local progression developed after 12 months. These cases suggest that some RCCs may be refractory to cryoablation. In cases of recurring local progression, switching from cryoablation to another ablation modality may be an alternative.
我们描述了三例肾细胞癌（RCC）患者，其局部肿瘤出现复发性进展，即在对局部进展性肿瘤进行重复冷冻消融后出现局部失败。尽管在首次冷冻消融时形成了足够大的冰球边缘，但在所有病例中，首次局部进展接受冷冻消融后均出现了第二次局部进展。两例患者的第二次局部进展采用微波消融治疗，并在随访中得到控制。一例患者进行了第三次冷冻消融，但12个月后出现了第三次局部进展。这些病例表明，一些肾细胞癌可能对冷冻消融治疗具有难治性。对于复发性局部进展的病例，从冷冻消融转换为另一种消融方式可能是一种选择。
