Pneumothorax and unintended arterial puncture are well-known complications of central venous (CV) access via the internal jugular vein (IJV), whereas injury to nerves around the IJV is a relatively rare complication. We describe the case of a male patient in his 60s who developed Horner syndrome after CV port placement via the IJV. We also point out the anatomical nerve structures around the IJV that clinicians should be aware of in order to minimize the risk of nerve injury during CV access. Additionally, with a brief literature review, we describe other nerve injuries that can be caused by CV access.