Gill Brian J A, Higgins Dominique M, Banu Matei A, Argenziano Michael G, Feldstein Neil A, Bruce Jeffrey N
Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York.
Neurosurg Focus Video. 2021 Jul 1;5(1):V3. doi: 10.3171/2021.4.FOCVID2151. eCollection 2021 Jul.
Germ cell tumors account for up to 53% of the malignant lesions found in the pineal region and are typically managed with a combination of radiation therapy and chemotherapy. Malignant somatic transformation of intracranial germ cell tumors is exceedingly rare and has only been reported on two other occasions. Here the authors present the case of a pineal yolk sac tumor that failed optimum first-line treatment and underwent malignant somatic transformation to an enteric mucinous adenocarcinoma requiring surgical intervention. This video demonstrates the technical nuances of the occipital transtentorial approach and the safe microsurgical dissection of lesions within the pineal region. The video can be found here: https://stream.cadmore.media/r10.3171/2021.4.FOCVID2151.
生殖细胞肿瘤占松果体区恶性病变的比例高达53%,通常采用放射治疗和化疗相结合的方式进行治疗。颅内生殖细胞肿瘤的恶性体细胞转化极为罕见,此前仅另有两例报道。本文作者报告了一例松果体卵黄囊瘤病例,该病例一线治疗未达最佳效果,随后发生恶性体细胞转化,转变为需要手术干预的肠黏液腺癌。本视频展示了枕下经小脑幕入路的技术细节以及松果体区内病变的安全显微手术解剖。视频链接如下:https://stream.cadmore.media/r10.3171/2021.4.FOCVID2151