Lykouras L, Vassilopoulos D, Voulgari A, Stefanis C, Malliaras D
Psychiatry Res. 1987 Jul;21(3):277-83. doi: 10.1016/0165-1781(87)90032-1.
To quantify the contribution of genetic factors in the pathogenesis of delusional depression, the incidence of major depression in the first degree relatives of 77 delusional, 76 nondelusional depressive patients, and 153 age- and sex-matched controls was calculated in a case-control study. The morbid risk for psychiatric disorders, including major depression and bipolar I disorder, did not distinguish the two proband groups. The segregation analysis showed that the model of multifactorial inheritance fits best to our results. Heritability was estimated on the basis of a threshold model for multifactorial inheritance, and a high contribution of genetic factors for both subgroups was found.
为了量化遗传因素在妄想性抑郁症发病机制中的作用，在一项病例对照研究中，计算了77名妄想性抑郁症患者、76名非妄想性抑郁症患者以及153名年龄和性别匹配的对照者的一级亲属中重度抑郁症的发病率。包括重度抑郁症和双相I型障碍在内的精神疾病的患病风险并未区分这两组先证者。分离分析表明，多因素遗传模型最符合我们的研究结果。基于多因素遗传的阈值模型估计了遗传度，发现遗传因素对两个亚组都有很高的贡献。
