胶黏剂如何黏附在细胞表面？
What Glues the Glue to the Cell Surface?
机构信息
Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
出版信息
J Bacteriol. 2022 Nov 15;204(11):e0038622. doi: 10.1128/jb.00386-22. Epub 2022 Oct 26.
Abstract
In the , a highly adhesive polysaccharide called the holdfast mediates attachment to exogenous surfaces. The mechanism by which this polysaccharide is anchored to the cell envelope is not well defined. N. K. Chepkwony, G. G. Hardy, and Y. V. Brun (J Bacteriol 204:e00273-22, 2022, https://doi.org/10.1128/jb.00273-22) report the characterization of HfaE, a localized surface protein with amyloid-like properties that is required for robust holdfast anchoring. This study expands our understanding of the protein factors that attach a bacterial "superglue" to the surface of the cell.
摘要
在这篇论文中，一种名为附着胞的高粘性多糖介导了对外源表面的附着。然而，这种多糖与细胞包膜结合的机制尚不清楚。N. K. Chepkwony、G. G. Hardy 和 Y. V. Brun（J Bacteriol 204:e00273-22, 2022, https://doi.org/10.1128/jb.00273-22）报道了 HfaE 的特征，HfaE 是一种具有淀粉样特性的局部表面蛋白，是牢固附着胞附着所必需的。这项研究扩展了我们对将细菌“超级胶水”附着到细胞表面的蛋白质因素的理解。
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HfaE Is a Component of the Holdfast Anchor Complex That Tethers the Holdfast Adhesin to the Cell Envelope.HfaE 是固着锚复合物的一个组成部分，将固着黏附素固定在细胞包膜上。
J Bacteriol. 2022 Nov 15;204(11):e0027322. doi: 10.1128/jb.00273-22. Epub 2022 Sep 27.
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The biofilm life cycle: expanding the conceptual model of biofilm formation.生物膜的生命周期：扩展生物膜形成的概念模型。
Nat Rev Microbiol. 2022 Oct;20(10):608-620. doi: 10.1038/s41579-022-00767-0. Epub 2022 Aug 3.
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Mol Microbiol. 2022 May;117(5):1023-1047. doi: 10.1111/mmi.14887. Epub 2022 Mar 4.
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In Situ Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface Layer.完整脂多糖结合细菌表面层的原位结构。
Cell. 2020 Jan 23;180(2):348-358.e15. doi: 10.1016/j.cell.2019.12.006. Epub 2019 Dec 26.
5
Composition of the Holdfast Polysaccharide from .褐藻胶多糖固着器的组成。
J Bacteriol. 2019 Aug 8;201(17). doi: 10.1128/JB.00276-19. Print 2019 Sep 1.
6
A Multiprotein Complex Anchors Adhesive Holdfast at the Outer Membrane of Caulobacter crescentus.多蛋白复合物将黏附素锚定于新月柄杆菌的外膜上。
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