Safiullina A A, Uskach T M, Saipudinova K M, Tereshchenko S N, Chazova I E
Chazov National Medical Research Center of Cardiology.
Russian Medical Academy of Continuous Professional Education.
Ter Arkh. 2022 Oct 24;94(9):1115-1121. doi: 10.26442/00403660.2022.09.201837.
Obesity is an independent predictor of cardiovascular diseases (CVD), including heart failure (HF). Nevertheless, numerous studies have shown that patients with CVD who are overweight and slightly obese have a better short-term and moderate prognosis than thinner patients with CVD. This phenomenon has been called the obesity paradox. Understanding the obesity paradox is important in patients with HF, given the high prevalence of obesity in patients with HF. The article presents an overview of clinical studies devoted to the study of obesity as a risk factor for HF, the pathogenesis of HF in obesity, and highlights the issues of the obesity paradox and the treatment of obesity in this category of patients.
肥胖是心血管疾病(CVD)的独立预测因素,包括心力衰竭(HF)。然而,大量研究表明,超重和轻度肥胖的CVD患者比体重较轻的CVD患者具有更好的短期和中期预后。这种现象被称为肥胖悖论。鉴于HF患者中肥胖的高患病率,了解肥胖悖论对HF患者很重要。本文概述了致力于研究肥胖作为HF危险因素、肥胖中HF发病机制的临床研究,并强调了肥胖悖论问题以及此类患者的肥胖治疗。