Panevin T S, Bobkova A O, Karateev A E, Zotkin E G
Nasonova Research Institute of Rheumatology.
Ter Arkh. 2022 Jun 17;94(5):683-688. doi: 10.26442/00403660.2022.05.201490.
Sexual dimorphism of chronic diseases is a phenomenon determined by differences in the hormonal status of men and women. In this regard, estrogens, which have a complex effect on the body, are of great interest. In particular, estrogens play an important role in the natural control of pain and inflammation. A decrease in estrogen levels associated with menopause or iatrogenic effects (hysterectomy, use of aromotase inhibitors), as well as mutations of genes responsible for the synthesis of structural components of membrane estrogen receptors (ESR1 and ESR2), can significantly reduce the positive effects of these hormones. Deficiency of estrogen can become one of the reasons for the development of serious pathological changes in particular, the formation of chronic pain associated with the pathology of the musculoskeletal system.
慢性疾病的性别二态性是一种由男性和女性激素状态差异所决定的现象。在这方面，对身体具有复杂作用的雌激素备受关注。特别是，雌激素在疼痛和炎症的自然控制中发挥着重要作用。与绝经或医源性影响（子宫切除术、使用芳香化酶抑制剂）相关的雌激素水平下降，以及负责膜雌激素受体（ESR1和ESR2）结构成分合成的基因突变，都可能显著降低这些激素的积极作用。雌激素缺乏尤其可能成为严重病理变化发展的原因之一，即与肌肉骨骼系统病理相关的慢性疼痛的形成。
