Hisamatsu S, Takizawa Y
Radiat Res. 1987 Aug;111(2):334-9.
The retention of 241Am in mice 48 h after administration by gavage is reported here. The 241Am was given to mice in the form of either 241Am nitrate or 241Am citrate. The 241Am was also injected into rats in the same form. The homogenized livers of those rats were subsequently administered by gavage to another group of mice. The retention of 241Am citrate was 1.5 X 10(-2)% of the original dose and was the highest among the compounds examined. The retention of biologically incorporated 241Am into the liver as 241Am nitrate and as 241Am citrate was 2.4 X 10(-3) and 2.6 X 10(-3)%, respectively, and was similar to the retention of 241Am nitrate, which was 2.8 X 10(-3)%. The ratio of the retention in the carcass to that in the liver for the 241Am citrate was lower than that of the 241Am nitrate and the biologically incorporated 241Am. This difference indicates that the distribution of 241Am in the animal body depends on the chemical form administered. The retention of liver-incorporated 241Am as citrate after autolysis of the liver is similar to that of fresh liver-incorporated 241Am citrate.
本文报道了小鼠经口灌胃给予241Am后48小时内的滞留情况。241Am以硝酸241Am或柠檬酸241Am的形式给予小鼠。241Am也以相同形式注射到大鼠体内。随后将这些大鼠的匀浆肝脏经口灌胃给予另一组小鼠。柠檬酸241Am的滞留量为原始剂量的1.5×10（-2）%，是所检测化合物中滞留量最高的。以硝酸241Am和柠檬酸241Am形式生物掺入肝脏中的241Am的滞留量分别为2.4×10（-3）%和2.6×10（-3）%，与硝酸241Am的滞留量2.8×10（-3）%相似。柠檬酸241Am在胴体中的滞留量与在肝脏中的滞留量之比低于硝酸241Am和生物掺入的241Am。这种差异表明241Am在动物体内的分布取决于所给予的化学形式。肝脏自溶后以柠檬酸形式掺入肝脏的241Am的滞留情况与新鲜肝脏掺入柠檬酸241Am的滞留情况相似。
