内生真菌 Phomopsis sp. 是具有杀蚊幼虫活性的 3-硝基丙酸的来源，对埃及伊蚊（Linnaeus 1762，双翅目：蚊科）有效。
Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae).
机构信息
Universidade Federal do Amazonas, Instituto de Ciências Exatas e Tecnologia, Itacoatiara, AM, Brasil.
Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2022 Oct 24;55:e00182022. doi: 10.1590/0037-8682-0018-2022. eCollection 2022.
BACKGROUND
Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti.
METHODS
Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti.
RESULTS
We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure.
CONCLUSIONS
The results indicated that 3-nitropropionic acid exerted larvicidal activity.
背景
埃及伊蚊是寨卡、基孔肯雅热、黄热病和登革热等病毒的主要传播媒介。在这种情况下，进行了一项生物监测化学研究，以评估内生真菌 Phomopsis sp. 的粗提物对埃及伊蚊幼虫的活性。
方法
对粗提物、馏分和分离物质进行了体外试验，以评估对埃及伊蚊三龄幼虫的活性。
结果
在幼虫暴露 24 小时后，我们分离出了 LC50 为 15.172 ppm、LC90 为 18.178 ppm 的 3-硝基丙酸。
结论
结果表明 3-硝基丙酸具有杀幼虫活性。
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