Ramírez-Soto Max Carlos, Ortega-Cáceres Gutia, Garay-Uribe Jose
Centro de Investigación en Salud Pública, Facultad de Medicina Humana, Universidad San Martín de Porres, Lima 15011, Peru.
Facultad de Ciencias de la Salud, Universidad Tecnológica del Peru, Lima 15046, Peru.
Trop Med Infect Dis. 2022 Oct 19;7(10):317. doi: 10.3390/tropicalmed7100317.
Respiratory syncytial virus (RSV) and influenza infections are important causes of respiratory illness associated with hospitalizations in children in Peru; however, comparisons of RSV and influenza hospitalization across all age groups are not available in Peru. Therefore, we conducted an observational, retrospective study between May 2015 and October 2021 using hospitalization from RSV and influenza infection data obtained from SUSALUD (open data) in Peru to compare the baseline characteristics of sex, age, region, and infection type. For the study, 2696 RSV-infected and 1563 influenza-infected hospitalized patients from different age groups were included. Most hospitalizations from RSV infection and the influenza virus occurred in children <5 years of age (86.1% vs. 32.2%, respectively). Compared with influenza infection, RSV infection was less likely to occur in individuals ≥5 years of age (adjusted odds ratio (aOR) = 0.07; 95% confidence interval (CI), 0.06−0.08; p < 0.0001; compared to <5 years of age), and more likely to occur in highlands (aOR = 1.75; 95% CI, 1.46−2.07; p < 0.0001, compared to coast region), and jungle region (aOR = 1.75; 95% CI, 1.27−2.41; p = 0.001, compared to coast region). Among the respiratory complications, RSV pneumonia was less likely to occur between different age groups (aOR = 0.29; 95% CI, 0.22−0.37; p < 0.0001, compared to <5 years of age), compared with influenza pneumonia. These findings on the RSV-hospitalization and its complications are helpful for health services planning and may increase awareness of the Peruvian population’s RSV and influenza disease burden.
呼吸道合胞病毒（RSV）感染和流感感染是秘鲁儿童因呼吸道疾病住院的重要原因；然而，秘鲁尚无所有年龄组RSV感染和流感住院情况的比较数据。因此，我们于2015年5月至2021年10月开展了一项观察性回顾性研究，利用从秘鲁SUSALUD（开放数据）获取的RSV感染和流感感染住院数据，比较性别、年龄、地区和感染类型的基线特征。该研究纳入了不同年龄组的2696例RSV感染住院患者和1563例流感感染住院患者。RSV感染和流感病毒导致的住院大多发生在5岁以下儿童中（分别为86.1%和32.2%）。与流感感染相比，RSV感染在5岁及以上个体中发生的可能性较小（调整优势比（aOR）=0.07；95%置信区间（CI），0.06−0.08；p<0.0001；与5岁以下相比），而在高地地区发生的可能性较大（aOR = 1.75；95% CI，1.46−2.07；p<0.0001，与沿海地区相比），在丛林地区发生的可能性也较大（aOR = 1.75；95% CI，1.27−2.41；p = 0.001，与沿海地区相比）。在呼吸道并发症中，与流感肺炎相比，RSV肺炎在不同年龄组之间发生的可能性较小（aOR = 0.29；95% CI，0.22−0.37；p<0.0001，与5岁以下相比）。这些关于RSV住院及其并发症的研究结果有助于卫生服务规划，并可能提高秘鲁民众对RSV和流感疾病负担的认识。
