Betancort-Plata Christian, Lopez-Delgado Laura, Jaén-Sanchez Nieves, Tosco-Nuñez Tomás, Suarez-Hormiga Laura, Lavilla-Salgado Carmen, Pisos-Álamo Elena, Hernández-Betancor Araceli, Hernández-Cabrera Michele, Carranza-Rodríguez Cristina, Briega-Molina Marta, Pérez-Arellano José-Luis
Unidad de Enfermedades Infecciosas y Medicina Tropical, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Servicio de Microbiología y Parasitología, Hospital Universitario Insular de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Trop Med Infect Dis. 2022 Oct 19;7(10):318. doi: 10.3390/tropicalmed7100318.
The clinical and epidemiological data of the recent outbreak of monkeypox (MPX) differ from previous reports. One difference is the epidemiological profile; the disease mainly affects a subgroup of MSM (men who have sex with men) with high-risk sexual behaviors, frequently persons living with human immunodeficiency virus (PLHIV).
In this observational analysis, all patients with PCR (polymerase chain reaction)-confirmed MPX attending an Infectious Diseases and Tropical Medicine Unit in Gran Canaria (Spain) between May and July 2022 were considered.
In total, 42 men were included; 88% were identified as MSM, with a median age of 40 years. Only 43% were born in Spain. All the patients had systemic symptoms and skin lesions. The distribution of lesions was more frequent in the genital/anal region, and the involvement of hands and feet was less common. Fever and lymphadenopathies were less frequent than in other series. Other unusual manifestations were proctitis, pharyngitis and penile-scrotal edema. Half of the patients had other associated infections (mainly STIs, sexually transmitted infections), and 60% of the monkeypox patients had PLHIV (People Living with HIV). When comparing the clinical characteristics between HIV-positive and -negative patients, we found three main differences: (i) a higher frequency of perioral lesions, (ii) a higher frequency of pharyngitis and (iii) a higher number of sexually transmitted infections in HIV-positive patients.
The clinical findings in this outbreak of MPX had great variability in presentation. Several clinical differences were found in PLHIV-coinfected patients.
近期猴痘（MPX）疫情的临床和流行病学数据与以往报告有所不同。其中一个差异在于流行病学特征；该疾病主要影响有高危性行为的男男性接触者（MSM）亚组，常见于感染人类免疫缺陷病毒（PLHIV）的人群。
在这项观察性分析中，纳入了2022年5月至7月期间在西班牙大加那利岛一家传染病与热带医学科就诊且经聚合酶链反应（PCR）确诊为猴痘的所有患者。
共纳入42名男性；88%被确定为男男性接触者，中位年龄为40岁。只有43%出生于西班牙。所有患者均有全身症状和皮肤病变。病变分布在生殖器/肛门区域更为常见，手部和足部受累较少见。发热和淋巴结病比其他系列报道的更为少见。其他不寻常表现包括直肠炎、咽炎和阴茎阴囊水肿。一半的患者有其他相关感染（主要是性传播感染，STIs），60%的猴痘患者感染了人类免疫缺陷病毒（PLHIV）。在比较HIV阳性和阴性患者的临床特征时，我们发现了三个主要差异：（i）HIV阳性患者口周病变的发生率更高，（ii）咽炎的发生率更高，（iii）HIV阳性患者的性传播感染数量更多。
此次猴痘疫情的临床表现差异很大。在合并感染HIV的患者中发现了一些临床差异。
